Preferences help
enabled [disable] Abstract
Number of results
2003 | 50 | 2 | 543-548
Article title

Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.

Title variants
Languages of publication
Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations anthocyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.
Physical description
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Department of Chemistry and Clinical Biochemistry, Medical University, Łódź, Poland
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Department of Chemistry and Clinical Biochemistry, Medical University, Łódź, Poland
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Department of Human Physiology and Biophysics, Medical University, Łódź, Poland
  • Bertuglia S. (1995) Efect of Vaccinium myrtillus anthocyanosides on ischemia reperfusion injury in hamster cheek pouch microcirculation. Pharmacol Res.; 31: 183-7.
  • Blasco J, Puppo J. (1999) Effect of heavy metals (Cu, Cd and Pb) on aspartate and alanine aminotransferase in Ruditapes philippinarum (Mollusca: Bivalvia). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol.; 122: 253-63.
  • Choudhury H, Harvey T, Thayer WC, Lockwood TF, Stiteler WM, Goodrum PE, Hassett JM, Diamond GL. (2001) Urinary cadmium elimination as a biomarker of exposure for evaluating a cadmium dietary exposure - biokinetics model. J Toxicol Environ Health A.; 63: 321-350.
  • Chun YS, Choi E, Kim GT, Choi H, Kim CH, Lee MJ, Kimm S, Park JW. (2000) Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha. Eur J Biochem.; 267: 4198-204.
  • Hertog MG, Hollman PC, Katan MB, Kromhout D. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer.; 20: 21-9.
  • Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Umemura T, Marumo F. (1996) Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol Appl Pharmacol.; 137: 228-36.
  • Hollis L, Hogstrand C, Wood CM. (2001) Tissue- specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout. Arch Environ Contam Toxicol.; 41: 468-74.
  • Jarup L. (2002) Cadmium overload and toxicity. Nephrol Dial Transplant.; 17 (Suppl 2): 35-9.
  • Jarup L, Hellstrom L, Alfven T, Carlsson MD, Grubb A, Persson B, Pettersson C, Spang G, Schultz A, Elinder CG. (2000) Low level exposure to cadmium and early kidney damage: the OSCAR study. Occup Environ Med.; 57: 668-72.
  • Klos A. (2001) Lead, cadmium and mercury content in meals planned for consumption in selected kindergartens in Warsaw. IV International Scientific-Technical Conference, Warsaw 4-5X.
  • Kowalczyk E, Jankowski A, Niedworok J, Smigielski J, Tyslerowicz P. (2002) Effect of long-term cadmium intoxication on selected biochemical parameters in experimental animals. Pol J Environ Stud.; 11: 599-601.
  • Liu J, Habeebu SS, Liu Y, Klaassen CD. (1998) Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats. Toxicol Appl Pharmacol.; 153: 48-58.
  • Mackova NO, Lenikova S, Fedorocko P, Brezani P. (1996) Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 2. Relationship to the number of circulating blood cells and haemopoiesis. Physiol Res.; 45: 101-6.
  • Novelli EL, Vieira EP, Rodrigues NL, Ribas BO. (1998) Risk assessment of cadmium toxicity on hepatic and renal tissues of rats. Environ Res.; 79: 102-5.
  • Oszmianski J. (2001) Aronia ( Aronia melanocarpa Elliot) fruits and skullcap (Scutellaria baicalensis Georgi) roots are very high in biologically active flavonoids. Farm Pol.; 15: 726-30.
  • Piotrowski JK, Moniuszko-Jakoniuk J. (1995) Zarys toksykologii kadmu. Medycyna Pracy.; 5 (Suplp. 5): 32-6.
  • Ryan PB, Huet N, Maclntosh DL. (2000) Longitudinal investigation of exposure to arsenic, cadmium and lead in drinking water. Environ Health Perspect.; 108: 731-5.
  • Sarkar S, Yadav P, Bhatnagar D. (1998) Lipid peroxidative damage on cadmium exposure and alterations in antioxidant system in rat erythrocytes: a study with relation to time. Biometals.; 11: 153-7.
  • Sauer JM, Waalkes MP, Hooser SB, Kuester RK, McQueen CA, Sipes IG. (1997) Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat. Toxicology.; 121: 155-64.
  • Shaikh ZA, Jordan SA, Tang WF. (1999) Protection against chronic cadmium toxicity by caloric restriction. Toxicology.; 133: 93-103.
  • Shibutani M, Mitsumori K, Satoh S, Hiratsuka H, Satoh M, Sumiyoshi M, Nishijima M, Katsuki Y, Suzuki J, Nakagawa J, Akagi T, Imazawa T, Ando M. (2001) Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months. J Toxicol Sci.; 26: 337-58.
  • Stohs SJ, Bagchi D, Hassoun E, Bagchi M. (2001) Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol.; 20: 77-82.
  • Subarnas A, Wagner H. (2000) Analgesic and anti-inflammatory activity of the proanthocyanidin shellegueain A from Polypodium feei METT. Phytomedicine.; 7: 401-5.
  • Tsuda T, Horio F, Kitoh J, Osawa T. (1999) Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch Biochem Biophys.; 368: 361-6.
  • Wang HK. (2000) The therapeutic potential of flavonoids. Expert Opin Investig Drugs.; 9: 2103-19.
  • Wawer I. (2001) Anthocyanidins, structure and antioxidant properties. Farm Pol.; 15: 728-31.
  • Wolniak M. (2002) Mechanisms of antioxidative action of anthocyanins. Farm Pol.; 20: 931-4.
  • Yamano T, Kosanke SD, Rikans LE. (1999) Attenuation of cadmium-induced liver injury in senescent male Fischer 344 rats: role of metallothionein and glutathione. Toxicol Appl Pharmacol.; 161: 225-30.
  • Yiin SJ, Chern CL, Sheu JY, Tseng WC, Lin TH. (1999) Cadmium induced renal lipid peroxidation in rats and protection by selenium. J Toxicol Environ Health A.; 57: 403-13.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.