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2003 | 50 | 2 | 489-495
Article title

Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer.

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EN
Abstracts
EN
Plasminogen activator inhibitor 1 (PAI-1) content in colorectal cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumours predict poor prognosis. The gene encoding PAI-1 is highly polymorphic and PAI-1 gene variability could contribute to the level of PAI-1 biosynthesis. In the present work the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in 92 subjects with colorectal cancer in samples of cancer tissue and distant mucosa samples as well as in blood were investigated. Blood samples age matched healthy individuals (n = 110) served as control. The 1334G/A polymorphism was determined by PCR amplification using allele specific primers. No differences in the genotype distributions and allele frequencies between blood, distant mucosa samples and cancer tissue were detected. However, the distribution of the genotypes of the 1334G/A polymorphism in patients differed significantly (P <0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between the colorectal cancer subjects and controls (P <0.05). The results support the hypothesis that the 1334G/A polymorphism may be associated with the incidence of colorectal cancer.
Publisher

Year
Volume
50
Issue
2
Pages
489-495
Physical description
Dates
published
2003
received
2002-04-22
revised
2003-04-22
accepted
2003-05-19
Contributors
author
  • Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother's Memorial Hospital, Łódź, Poland
  • Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother's Memorial Hospital, Łódź, Poland
author
  • Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother's Memorial Hospital, Łódź, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv50i2p489kz
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