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2002 | 49 | 4 | 999-1004
Article title

Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.

Content
Title variants
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EN
Abstracts
EN
Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.
Publisher

Year
Volume
49
Issue
4
Pages
999-1004
Physical description
Dates
published
2002
received
2001-11-13
revised
2002-07-19
accepted
2002-11-12
Contributors
  • Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland
  • Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland
author
  • Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland
  • Department of Gynaecology, Medical Academy of Białystok, Białystok, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i4p999kz
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