Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.

• Authors: Krzysztof Sobolewski , Edward Bańkowski , Jerzy Pałka , Stefan Jaworski
• Languages of publication: EN

Abstracts

EN

Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.

Keywords

EN

umbilical cord artery; fibroblast growth factor; Wharton's jelly; pre-eclampsia; EPH-gestosis

• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 4
• Pages: 999-1004

Dates

published

2002

received

2001-11-13

revised

2002-07-19

accepted

2002-11-12

Contributors

author

Krzysztof Sobolewski

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Edward Bańkowski

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Jerzy Pałka

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Stefan Jaworski

• Department of Gynaecology, Medical Academy of Białystok, Białystok, Poland

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