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2002 | 49 | 4 | 877-889
Article title

Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.

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EN
Abstracts
EN
In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
Publisher

Year
Volume
49
Issue
4
Pages
877-889
Physical description
Dates
published
2002
received
2002-09-15
revised
2002-11-15
accepted
2002-12-05
Contributors
  • Department of Molecular and Cellular Neurobiology, M. Nencki Institute of Experimental Biology, Warszawa, Poland
  • Department of Molecular and Cellular Neurobiology, M. Nencki Institute of Experimental Biology, Warszawa, Poland
References
  • Abbracchio MP, Burnstock G. (1994) Purinoceptors: are these families of P2X and P2Y purinoceptors? Pharmacol Ther.; 64: 445-75.
  • Abbracchio MP, Burnstock G. (1998) Purinergic signalling: phatophysiological roles. Jpn J Pharmacol.; 78: 113-45.
  • Baranska J, Chaban V, Czarny M, Sabala P. (1995) Changes in Ca2+concentration in phorbol ester and thapsigargin treated glioma C6 cells. The role of protein kinase C in regulation of Ca2+ entry. Cell Calcium.; 17: 207-15.
  • Baranska J, Przybylek K, Sabala P. (1999) Capacitative calcium entry. Glioma C6 as a model of nonexcitable cells. Pol J Pharmacol.; 51: 153-62.
  • Belardinelli L. (1993) Adenosine system in heart. Drug Dev Res.; 28: 263-7.
  • Berridge MJ. (1993) Inositol trisphosphate and calcium signalling. Nature.; 361: 315-25.
  • Berridge MJ. (1995) Capacitative calcium entry. Biochem J.; 312: 1-11.
  • Boarder MR, Hourani SM. (1998) The regulation of vascular function by P2 receptors: multiple sites and multiple receptors. Trends Pharmacol Sci.; 19: 99-107.
  • Bodin P, Burnstock G. (2001) Purinergic signalling: ATP release. Neurochem Res.; 26: 959-69.
  • Boeynaems JM, Communi D, Savi P, Herbert JM. (2000) P2Y receptors: in the middle of the road. Trends Pharmacol Sci.; 21: 1-3.
  • Boyer JL, Lazarowski ER, Chen X, Harden TK. (1993) Identification of a P2Y1purinergic receptor that inhibits adenylate cyclase. J Pharmacol Exp Ther.; 267: 1140-6.
  • Burnstock G. (1972) Purinergic nerves. Pharmacol Rev.; 24: 509-81.
  • Burnstock G. (1978) A basis for distinguishing two types of purinergic receptor. In Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Straub RW, Bolis L. eds, pp 107-18. Raven Press, New York.
  • Chen W, Wieraszko A, Hogan MK, Yang H-A, Kornecki E, Ehrlich YH. (1996) Surface protein phosphorylation by ecto-protein kinase is required for the maintenance of hippocampal long-term potentiation. Proc Natl Acad Sci USA.; 93: 8688-93.
  • Chiono M, Mahey R, Tate G, Cooper DMF. (1995) Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. J Biol Chem.; 270: 1149-55.
  • Ciruela F, Saura C, Canela EI, Mallol J, Liluis C, Franco R. (1997) Ligand-induced phosphorylation, clustering and desensitization of A1adenosine receptors. Mol Pharmacol.; 52: 788-97.
  • Communi D, Parmentier M, Boeynaemes JM. (1996) Cloning, functional expression and tissue distribution of human P2Y6receptor. Biochem Biophys Res Commun.; 222: 303-8.
  • Communi D, Gonzalez NS, Detheux M, Brezillon S, Lannoy V, Parmentier M, Boeynaems JM. (2001) Identification of a novel human ADP receptor coupled to Gi. J Biol Chem.; 276: 41479-85.
  • Czajkowski R, Baranska J. (1999) Sphingosine and phorbol ester modulate protein kinase C activity and modify ATP-evoked calcium mobilization in glioma C6 cells. Biochem Biophys Res Commun.; 260: 614-8.
  • Czajkowski R, Lei L, Sabala P, Baranska J. (2002) ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y1and P2Y12. FEBS Lett.; 513: 179-83.
  • Dubyak GR. (1991) Signal transduction by P2 purinergic receptors for extracellular ATP. Am J Respir Cell Mol Biol.; 4: 295-300.
  • Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev.; 46: 143-56.
  • Fredholm BB, Abbracchio MP, Burnstok G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M. (1997) Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci.; 18: 79-82.
  • Furukawa S, Satoh K, Taira N. (1993) Opening of ATP-sensitive K+channels responsible for adenosine A2 receptor-mediated vasodepression does not involve a pertussis-toxin-sensitive G protein. Eur J Pharmacol.; 236: 255-62.
  • Grobben B, Anciaux K, Roymans D, Stefan C, Bollen M, Esmans EL, Slegers H. (1999) An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma. J Neurochem.; 72: 826-34.
  • Grobben B, Claes P, Van Kolen K, Roymans D, Fransen P, Sys SU, Slegers H. (2001) Agonists of the P2YACreceptor activate MAP kinase by a ras-independent pathway in rat C6 glioma. J Neurochem.; 78: 1325-38.
  • Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrshnan V, Van RB, Nurden A, Julius D, Conley PB. (2001) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature.; 409: 202-7.
  • Hur E-M, Kim K-T. (2002) G protein-coupled receptor signalling and cross-talk. Achieving rapidity and specificity. Cell Signal.; 14: 397-405.
  • Illes P, Norenberg W. (1993) Neuronal ATP receptors and their mechanism of action. Trends Pharmacol Sci.; 14: 50-4.
  • Jin JG, Tomlinson W, Kirk IR, Kim YB, Humphries RG, Kunapuli SP. (2001) The C6-2B glioma cell P2YACreceptor is pharmacologically and molecularly identical to the platelet P2Y12 receptor. Br J Pharmacol.; 133: 521-8.
  • Khakh BS, Kennedy C. (1998) Adenosine and ATP: progress in their receptors structures and functions. Trends Pharmacol Sci.; 19: 39-41.
  • King FB, Townsend-Nicholson A, Burnstock G. (1998) Metabotropic receptors for ATP and UTP: exploring the correspondence between native and recombinant nucleotide receptors. Trends Pharmacol Sci.; 19: 506-14.
  • Kitanaka J-I, Hashimoto H, Gotoh M, Mayum T, Baba A. (1992) Mechanism of extracellular ATP-stimulated phosphoinositide hydrolysis in rat glioma C6 cells. J Pharmacol Exp Ther.; 263: 1248-52.
  • Kurokawa M, Koga K, Kase H, Nakamura J, Kuwana Y. (1996) Adenosine A2Areceptor-mediated modulation of striatal acetylcholine release in vivo. J Neurochem.; 66: 1882-8.
  • Lazarowski ER, Harden TK. (1994) Identification of a uridine nucleotide selective G protein-linked receptor that activates phospholipase C. J Biol Chem.; 269: 11830-6.
  • Lin W-W, Chuang D-M. (1993) Extracellular ATP stimulates inositol phospholipid turnover and calcium flux in C6 glioma cells. Neurochem Res.; 18: 681-7.
  • Nicholas R, Watt WC, Lazarowski ER, Li Q, Harden TK. (1996) Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective and an ATP and UTP-specific receptor. Mol Pharmacol.; 50: 224-9.
  • Pianet I, Merle M, Labouesse J. (1989) ADP and indirectly ATP are potent inhibitors of cAMP production in intact isoproterenol stimulated C6 glioma cells. Biochem Biophys Res Commun.; 163: 1150-7.
  • Putney JW Jr, Bird GStJ. (1993) The inositol phosphate-calcium signalling system in nonexcitable cells. Endocr Rev.; 14: 610-31.
  • Rosado JA, Jenner S, Sage SD. (2000) A role for the actin cytoskeleton in the initiation and maintenance of store-mediated Ca2+entry in human platelets. Evidence for conformational coupling. J Biol Chem.; 275: 7527-33.
  • Sabala P, Amler E, Baranska J. (1997) Intracellular Ca2+signals induced by ATP and thapsigargin in glioma C6 cells. Neurochem Int.; 31: 55-64.
  • Sabala P, Czajkowski R, Przybylek K, Kalita K, Kaczmarek L, Baranska J. (2001) Two subtypes of G protein coupled nucleotide receptors, P2Y1and P2Y2 are involved in calcium signalling in glioma C6 cells. Br J Pharmacol.; 132: 393-402.
  • Sabala P, Targos B, Caravelli A, Czajkowski R, Lim D, Gragnaniello G, Santella L, Baranska J. (2002) Role of the actin cytoskeleton in store-mediated calcium entry in glioma C6 cells. Biochem Biophys Res Commun.; 296: 484-91.
  • Savi P, Labouret C, Delesque N, Guette F, Lupker J, Harbert JM. (2001) P2Y12, a new platelet ADP receptor target of clopiogrel. Biochem Biophys Res Commun.; 283: 379-83.
  • Schachter JB, Li Q, Boyer JL, Nicholas RA, Harden TK. (1996) Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Br J Pharmacol.; 118: 167-73.
  • Schachter JB, Boyer JL, Li Q, Nicholas RA, Harden TK. (1997) Fidelity in functional coupling of the rat P2Y1receptor to phospholipase C. Br J Pharmacol.; 122: 1021-24.
  • Selbie LA, Hill SJ. (1998) G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci.; 19: 87-93.
  • Stiles GL. (1992) Adenosine receptors. J Biol Chem.; 267: 6451-54.
  • Webb TE, Feolde E, Vigne P, Neary JT, Runberg A, Frelin C, Barnard EA. (1996) The P2Y purinoceptor in rat brain microvascular endothelial cells coupled to inhibition of adenylate cyclase. Br J Pharmacol.; 119: 1385-92.
  • Windscheif U. (1996) Purinoceptors: from history to recent progress. A review. J Pharm Pharmacol.; 48: 993-1011.
  • Zhang FL, Luo L, Gustafson E, Palmer K, Qiao X, Fan X, Yang S, Laz TM, Bayne M, Monsma F Jr. (2002) P2Y13: Identification and characterization of a novel GaI-coupled ADP receptor from human and mouse. J Pharmacol Exp Ther.; 301: 705-13.
  • Zimmermann M. (1994) Signalling via ATP in the nervous system. Trends Neurosci.; 17: 420-6.
Document Type
Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i4p877kz
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