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2002 | 49 | 4 | 823-828
Article title

Actin in human colon adenocarcinoma cells with different metastatic potential.

Content
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EN
Abstracts
EN
Four human colon adenocarcinoma cell line variants with different metastatic potential were used to examine whether a correlation exists between actin level, state of actin polymerization and invasiveness of tumour cells. Monomeric (G), total (T) and filamentous (F) actin were determined in the cytosolic fraction of these cells. A statistically significant decrease in G actin level and increase in the state of actin polymerization (measured by F:G actin ratio) were found in the cytosol of three cell variants with higher metastatic potential and invasiveness (EB3, 3LNLN, 5W) compared with the parental cell line (LS180). Our experimental data lead to the conclusion that there is a correlation between the metastatic capacity of human colon adenocarcinoma cells and the state of actin polymerization.
Publisher

Year
Volume
49
Issue
4
Pages
823-828
Physical description
Dates
published
2002
received
2002-10-20
revised
2002-11-04
accepted
2002-11-12
Contributors
author
  • Department of Cell Pathology, Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
author
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Department of Cell Pathology, Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i4p823kz
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