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2002 | 49 | 4 | 1005-1012
Article title

Inhibition of proteolytic processing of adenoviral proteins by ε-aminocaproic acid and ambenum in adenovirus-infected cells

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Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs ε-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.
Physical description
  • Institute of Microbiology and Virology NAS of Ukraine, Kyiv, Ukraine
  • Institute of Microbiology and Virology NAS of Ukraine, Kyiv, Ukraine
  • Institute of Microbiology and Virology NAS of Ukraine, Kyiv, Ukraine
  • Institute of Organic Chemistry NAS of Ukraine, Kyiv, Ukraine
  • Ukrainian Research Anti-Plague Institute, Odessa, Ukraine
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