Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.

• Authors: Krystyna Urbanska , Bożena Romanowska-Dixon , Zenon Matuszak , Janusz Oszajca , Patrycja Nowak-Sliwinska , Grażyna Stochel
• Languages of publication: EN

Abstracts

EN

Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.

Keywords

EN

melanoma; photodynamic therapy; indocyanine green

• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 2
• Pages: 387-391

Dates

published

2002

received

2000-09-25

revised

2002-03-18

accepted

2002-04-24

Contributors

author

Krystyna Urbanska

• Institute of Molecular Biology and Biotechnology, Jagiellonian University, Kraków, Poland

author

Bożena Romanowska-Dixon

• Ophthalmology Department, Collegium Medicum, Kraków, Poland

author

Zenon Matuszak

• Faculty of Physics and Nuclear Techniques, Academy of Mining and Metallurgy, Kraków, Poland

author

Janusz Oszajca

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

author

Patrycja Nowak-Sliwinska

• Institute of Molecular Biology and Biotechnology, Jagiellonian University, Kraków, Poland

author

Grażyna Stochel

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

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