The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.

• Authors: Maria M Bontemps-Gracz , Agnieszka Kupiec , Ippolito Antonini , Edward Borowski
• Languages of publication: EN

Abstracts

EN

Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic activity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between tumor cell lines with various types of drug exporting pumps.

Keywords

EN

acridine cytostatics; cytotoxic activity; multidrug resistance; antitumor compounds

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 1
• Pages: 87-92

Dates

published

2002

received

2001-09-10

revised

2002-01-20

accepted

2002-02-20

Contributors

author

Maria M Bontemps-Gracz

• Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Technical University of Gdańsk, Gdańsk, Poland

author

Agnieszka Kupiec

• Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Technical University of Gdańsk, Gdańsk, Poland

author

Ippolito Antonini

• Department of Chemical Sciences, University of Camerino, Camerino (MC), Camerino, Italy

author

Edward Borowski

• Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Technical University of Gdańsk, Gdańsk, Poland

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