Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis.

• Authors: Jarek Kobiela , Jacek Krajewski , Beata Kalińska-Błach , Tomasz Stefaniak
• Languages of publication: EN

Abstracts

EN

Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.

Keywords

EN

estrogen-induced carcinogenesis; protein carbonyl group; renal carcinogenesis; oxidative stress

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 1
• Pages: 51-58

Dates

published

2002

received

2001-11-13

revised

2002-01-07

accepted

2002-02-07

Contributors

author

Jarek Kobiela

• Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland

author

Jacek Krajewski

• Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland

author

Beata Kalińska-Błach

• Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland

author

Tomasz Stefaniak

• Department of General, Gastroenterological and Endocrinological Surgery, Medical University of Gdańsk, Gdańsk, Poland

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