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2002 | 49 | 1 | 43-49
Article title

Aromatic indolinic aminoxyls as antioxidants in cardiac sarcoplasmic reticulum lipid and protein oxidation.

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EN
Abstracts
EN
The results presented demonstrate the influence of aromatic indolinic aminoxyls: 1,2-dihydro-2-ethyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C2) and 1,2-dihydro-2-octadecyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C18) on oxidation of lipids and proteins of cardiac sarcoplasmic reticulum membranes. We have used doxorubicin and t-butyl hydroperoxide as agents inducing oxidative stress in isolated rat cardiac sarcoplasmic reticulum membrane system. Carbonyl groups were measured as the end product of membrane protein oxidation, and thiobarbituric acid reactive substances were assessed as a marker of lipid peroxidation. Inhibition of peroxidation of certain membrane components depends on the length of acyl chain. Aminoxyl IA-C2 inhibits the lipid peroxidation process while IA-C18 is an efficient protector against protein oxidation.
Publisher

Year
Volume
49
Issue
1
Pages
43-49
Physical description
Dates
published
2002
received
2001-11-13
revised
2002-01-02
accepted
2002-01-10
Contributors
  • Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland
  • Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland
author
  • Dipartimento di Scienze dei Materiali e della Terra, Universit di Ancona, Ancona, Italy
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i1p43kz
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