Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.

• Authors: Natalia Derebecka , Marcin Hołysz , Rafał Dankowski , Michał Wierzchowski , Wiesław H Trzeciak
• Languages of publication: EN

Abstracts

EN

Nitric oxide (NO) is synthesised in the vascular endothelium by nitric oxide synthase (NOS3) and is an important factor in the regulation of blood pressure. Impaired synthesis of NO due to mutations in the NOS3 gene is associated with hypertension. To date several allelic variants of the NOS3 gene have been identified and their possible linkage with hypertension investigated. We studied the distribution of genotypes and frequency of alleles of the G11T polymorphism in intron 23 of the NOS3 gene in patients with hypertension and in a control group of healthy individuals. The polymorphism was determined by PCR-RFLP analysis. The distribution of genotypes in the patients with hypertension and in the healthy individuals did not differ significantly from the values predicted from Hardy-Weinberg equilibrium for the general population. No major differences in the distribution of the G11T polymorphism in the patients and healthy individuals were found (P > 0.05).

Keywords

EN

nitric oxide synthase; gene polymorphism; hypertension; intron 23

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 1
• Pages: 263-268

Dates

published

2002

received

2002-01-31

revised

2002-02-13

accepted

2002-02-21

Contributors

author

Natalia Derebecka

• Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznań, Poland

author

Marcin Hołysz

• Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznań, Poland

author

Rafał Dankowski

• Cardiology Clinic, University of Medical Sciences, Poznań, Poland

author

Michał Wierzchowski

• Cardiology Clinic, University of Medical Sciences, Poznań, Poland

author

Wiesław H Trzeciak

• Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznań, Poland

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