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2002 | 49 | 1 | 227-232
Article title

Monitoring of urine nitric oxide (NO) related substrates and immunological competence in hematological malignancy.

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EN
Abstracts
EN
It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myelocytic leukemia. However, no significant correlation was observed between urine neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+16+ subset or serum IFN-β levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and urine neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.
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Year
Volume
49
Issue
1
Pages
227-232
Physical description
Dates
published
2002
received
2001-09-10
revised
2002-01-29
accepted
2002-02-12
Contributors
author
  • First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
  • First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
  • First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
  • First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
author
  • First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
References
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  • 2. Evans, T.J., Buttery, L.D.K., Carpenter, A., Springall, D.R., Polak, J.M. & Cohen, J. (1996) Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. Proc. Natl. Acad. Sci. U.S.A. 93, 9553-9558.
  • 3. Filep, J.G., Baron, C., Lachance, S., Perreault, C. & Chan, J.S.D. (1996) Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells. Blood 87, 5136-5143.
  • 4. Werner, E.R., Werner-Felmayer, G., Fuchs, D., Hausen, A., Reibnegger, G., Yim, J.J., Pfleiderer, W. & Wachter, H. (1990) Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. J. Biol. Chem. 265, 3189-3192.
  • 5. Ziegler, I., Schott, K., Lubbert, M., Herrmann, F., Schwulera, U. & Bacher, A. (1990) Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-γ and interleukin-2. J. Biol. Chem. 265, 17026-17030.
  • 6. Lim, K.L., Muir, K. & Powell, R.J. (1994) Urine neopterin: A new parameter for serial monitoring of disease activity in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 53, 743-748.
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  • 8. Hibiya, M., Teradaira, R., Sugimoto, T., Fujita, K. & Nagatsu, T. (1995) Simultaneous determination of N2-(3-aminopropyl)biopterin (oncopterin), biopterin and neopterin by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B Biomed Appl 672, 143- 148.
  • 9. Satoh, T., Brown, L.M., Blattner, W.A., Maloney, E.M., Kurman, C.C., Nelson, D.L., Fuchs, D., Wachter, H. & Tollerud, D.J. (1998) Serum neopterin, β2-microglobulin, soluble interleukin-2 receptors, and immunoglobulin levels in healthy adolescents. Clin. Immunol. Immunopathol. 88, 176-182.
  • 10. Rubin, L.A., Kurman, C.C., Fritz, M.E., Biddison, W.E., Boutin, B., Yarchoan, R. & Nelson, D.L. (1985) Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J. Immunol. 135, 3172-3177.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i1p227kz
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