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2002 | 49 | 1 | 177-183
Article title

New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases.

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EN
Abstracts
EN
A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 μM concentration.
Year
Volume
49
Issue
1
Pages
177-183
Physical description
Dates
published
2002
received
2001-09-10
revised
2001-12-20
accepted
2002-01-28
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i1p177kz
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