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2002 | 49 | 1 | 139-144
Article title

Cytotoxic effect of nitric oxide on human hematological malignant cells.

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EN
Abstracts
EN
We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.
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Year
Volume
49
Issue
1
Pages
139-144
Physical description
Dates
published
2002
received
2001-09-10
revised
2002-01-29
accepted
2002-02-12
Contributors
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
author
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
author
  • First Division, Department of Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv49i1p139kz
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