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2001 | 48 | 4 | 921-933
Article title

Protein phosphatase 2A: Variety of forms and diversity of functions

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Abstracts
EN
Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine-and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with the structural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr307 and methylation on C-terminal Leu309. Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction.
Publisher

Year
Volume
48
Issue
4
Pages
921-933
Physical description
Dates
published
2001
received
2001-10-24
accepted
2001-12-4
Contributors
  • Cell and Molecular Signaling Laboratory, Intercollegiate Faculty of Biotechnology Medical University of Gdańsk, Gdańsk, Poland
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, A. Pawińskiego 5a, 02-106 Warszawa, Poland
  • Cell and Molecular Signaling Laboratory, Intercollegiate Faculty of Biotechnology Medical University of Gdańsk, Gdańsk, Poland
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, A. Pawińskiego 5a, 02-106 Warszawa, Poland
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bwmeta1.element.bwnjournal-article-abpv48i4p921kz
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