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2001 | 48 | 4 | 1203-1207
Article title

Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.

Content
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EN
Abstracts
EN
G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.
Publisher

Year
Volume
48
Issue
4
Pages
1203-1207
Physical description
Dates
published
2001
received
2001-10-17
accepted
2001-11-12
Contributors
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
author
  • Department of Public Health, University School of Physical Education, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
References
  • 1. Palczewski, K., Kumasaka, T., Hori, Y., Behnke, C.A., Motoshima, H., Fox, B.A., Le Trong, I., Teller, D.C., Okada, T., Stenkamp, R.E., Yamamoto, M. & Miyano, M. (2000) Science 289, 739-745.
  • 2. Bourne, H.R. & Meng, E.C. (2000) Science 289, 733-734.
  • 3. Corpet, F. (1988) Nucleic Acids Res. 16, 10881-10890.
  • 4. Politowska, E., Kaźmierkiewicz, R., Wiegand, V., Fahrenholz, F. & Ciarkowski, J. (2001) Acta Biochim. Polon. 48, 83-93.
  • 5. SYBYL 6.6 (1999) Tripos Inc. 1699 South Hanley Rd., St. Louis, MO 63144, U.S.A.
  • 6. Case, D.A., Pearlman, D.A., Caldwell, J.W., Cheatham III, T.E., Ross, W.S., Simmerling, C., Darden,T., Merz., K.M., Stanton, R.V., Cheng, A., Vincent, J.J., Crowley, M., Ferguson, D.M., Radmer, R., Seibel, G.L., Singh, U.C., Weiner, P.K. & Kollman, P.A. (1997) AMBER, v.5.0, University of California,San Francisco, CA, U.S.A.
  • 7. Bernstein, F.C., Koetzle, T.F., Williams, G.J., Meyer, E.E.J., Brice, M.D., Rodgers, J.R., Kennard,O., Shimanouchi, T. & Tsanumi, M. (1977) J. Mol. Biol. 112, 535-542.
  • 8. Guex, N., Diemand, A., Schwede, T. & Peitsch, M. (2000) Swiss PDB Viewer, Glaxo WellcomeExperimental Res.
  • 9. Toh, K.K.H. (1995) PlotMTV Program, Ver1.4.1-16 Copyright: (C); e-mail: ktoh@td2cad.intel.com
  • 10. Baldwin, J.M., Schertler, G.F. & Unger, V.M. (1997) J. Mol. Biol. 272, 144-164.
  • 11. Pogozheva, I.D., Lomize, A.L. & Mosberg, H.I. (1997) Biophys. J. 72,1963-1985.
  • 12. Ślusarz, R., Kaźmierkiewicz, R., Gieldoń, A., Lammek, B. & Ciarkowski, J. (2001) Acta Biochim. Polon. 48, 131-135.
  • 13. Gether, U. & Kobilka, B.K. (1998) J. Biol. Chem. 273, 17979-17982
  • 14. Oliveira, L., Paiva, A.C.M., Sander, C. & Vriend, G. (1994) Trends Pharmacol. Sci. 15, 170-172.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i4p1203kz
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