PL EN


Preferences help
enabled [disable] Abstract
Number of results
2001 | 48 | 4 | 1185-1189
Article title

Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid.

Content
Title variants
Languages of publication
EN
Abstracts
EN
Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activities of CATA.
Publisher

Year
Volume
48
Issue
4
Pages
1185-1189
Physical description
Dates
published
2001
received
2001-10-1
accepted
2001-11-4
Contributors
author
  • Peptide Laboratory, Haartman Institute, Helsinki University, Helsinki, Finland
  • King Gustav V Research Institute, Karolinska Hospital, Stockholm, Sweden
  • Department of Microbiology and Immunology, A-5301 Medical Center North, Vanderbilt University, Nashville, Tennessee, U.S.A.
author
  • Protein Analysis Center, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  • Faculty of Chemistry and Regional Laboratory, Jagiellonian University, Kraków, Poland
  • Peptide Laboratory, Haartman Institute, Helsinki University, Helsinki, Finland
References
  • 1. Simmaco, M., Mignogna, G., Canofeni, S., Miele, R., Mangoni, M.L. & Barra, D. (1996) Eur. J.Biochem. 242, 788-792.
  • 2. Mangoni, M.L., Rinaldi, A.C., Di Giulio, A., Mignogna, G., Bozzi, A., Barra, D. & Simmaco, M. (2000) Eur. J. Biochem. 267, 1447-1454.
  • 3. Steiner, H., Hultmark, D., Engström, C, Bennich, H. & Boman, H.G. (1981) Nature 292, 246-248.
  • 4. Andreu, D., Ubach, J., Boman, A., Wahlin, B., Wade, D., Merrifield, R.B. & Boman, H.G. (1992) FEBS Lett. 296, 190-194.
  • 5. Oh, H., Hedberg, M., Wade, D. & Edlund, C. (2000) Antimicrob. Agents Chemother. 44, 68-72.
  • 6. Wade, D., Silberring, J., Soliymani, R., Heikkinen, S., Kilpelainen, I., Lankinen, H. & Kuusela, P. (2000) FEBS Lett. 479, 6-9.
  • 7. Nylander, I., Tan-No, K., Winter, A. & Silberring, J. (1995) Life Sci. 57, 123-129.
  • 8. Ponti, D., Mignogna, G., Mangoni, M.L., DeBiase, D., Simmaco, M. & Barra, D. (1999) Eur. J. Biochem. 263, 921-927.
  • 9. Rollins-Smith, L.A., Doersam, J.K., Longcore, J.E., Taylor, S.K., Shamblin, J.C., Carey, C. & Zasloff, M.A. (2001) Dev. Comp. Immunol. 26, 63-72
  • 10. Murray, R.K., Granner, D.K., Mayes, P.A. & Rodwell, V.W. (2000) Harper's Biochemistry25th edn.,pp. 868-869, Appleton & Lange, Stamford, Connecticut.
  • 11. Boman, H.G. (2000) Immunol Rev. 173, 5-16.
  • 12. Wade, D., Andreu, D., Mitchell, S.A., Silveira, A.M., Boman, A., Boman, H.G. & Merrifield, R.B. (1992) Int. J. Pept. Protein Res. 40, 429-436.
  • 13. Daszak, P., Berger, L., Cunningham, A.A., Hyatt, A.D., Green, D.E. & Speare, R. (1999) Emerg.Infect. Dis. 5, 735-748.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i4p1185kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.