Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydropheny-alanine.

• Authors: Dawid Siodłak , Małgorzata A Broda , Barbara Rzeszotarska , Anna E Kozioł , Izabela Dybała
• Languages of publication: EN

Abstracts

EN

Conformational preferences of Ac-ΔAla-NMe2 and Ac-(Z)-ΔPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.

Keywords

EN

alanine and phenylalanine derivatives; N',N'-dimethylamides; X-ray crystallography; α,β-dehydroamino acids; theoretical calculations

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1179-1183

Dates

published

2001

received

2001-10-01

accepted

2001-11-29

Contributors

author

Dawid Siodłak

• Institute of Chemistry, University of Opole, Opole, Poland

author

Małgorzata A Broda

• Institute of Chemistry, University of Opole, Opole, Poland

author

Barbara Rzeszotarska

• Institute of Chemistry, University of Opole, Opole, Poland

author

Anna E Kozioł

• Faculty of Chemistry, Maria Curie-Skłodowska University Lublin, Lublin, Poland

author

Izabela Dybała

• Faculty of Chemistry, Maria Curie-Skłodowska University Lublin, Lublin, Poland

References

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