Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydropheny-alanine.
Languages of publication
Conformational preferences of Ac-ΔAla-NMe2 and Ac-(Z)-ΔPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.
- 1. Palmer, D.E., Pattaroni, Ch., Nunami, K., Chadha, R.K., Goodman, M., Wakamiya, T., Fukase, K.,Horimoto, S., Kitazawa, M., Fujita, H., Kubo, A. & Shiba, T .(1992). J. Am. Chem. Soc. 114, 5634-5642.
- 2. Souhassou, M., Lecomte, C., Ghermani, N.-E., Rohmer, M.M., Wiest, R., Benard, M. & Blessing, R.H.(1992) J. Am. Chem. Soc. 114, 2371-2382.
- 3. Zimmerman, S.S., Pottle, M.S., Némethy, G. & Scheraga,H.A. (1977) Macromolecules 10, 1-9.
- 4. Dunitz, J.D. & Winkler, F.K. (1975) Acta Crystallogr. B31, 251-263.
Publication order reference