Synthesis and binding properties of deltorphin I analogues containing (R) and (S)-α-hydroxymethylnaphtylalanine.

• Authors: Aleksandra Olma , Agnieszka Gniadzik , Andrzej W Lipkowski , Magdalena Łachwa
• Languages of publication: EN

Abstracts

EN

New analogues of deltorphin I (DT I), in which the phenylalanine residue in position 3 is substituted with amphiphilic α,α-disubstituted amino acid enantiomers, (R) and (S)-α-hydroxymethylnaphtylalanine, were synthesized and tested for μ and δ opioid receptor affinity and selectivity. Although both analogues have lower affinity to δ receptors than DT I, they both expressed specificity to δreceptors.

Keywords

EN

deltorphin I analogues; amphiphilic amino acids; α,α-disubstituted amino acids; opioid peptides; opioid receptor binding; α-hydroksymethylamino acids

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1165-1168

Dates

published

2001

received

2001-09-16

accepted

2001-11-6

Contributors

author

Aleksandra Olma

• Institute of Organic Chemistry, Technical University, Łódź, Poland

author

Agnieszka Gniadzik

• Institute of Organic Chemistry, Technical University, Łódź, Poland

author

Andrzej W Lipkowski

• Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland

author

Magdalena Łachwa

• Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland

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