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Abstracts
Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).
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Journal
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Volume
Issue
Pages
1151-1154
Physical description
Dates
published
2001
received
2001-09-19
accepted
2001-12-7
Contributors
author
- Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
author
- Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
author
- Faculty of Chemistry, Jagiellonian University, Kraków, Poland
author
- Faculty of Chemistry, Jagiellonian University, Kraków, Poland
author
- Department of Immunology, Medical University of Łódź, Łódź, Poland
author
- Department of Immunology, Medical University of Łódź, Łódź, Poland
author
- Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
References
- 1. Ellis, G. & West, G.B. (1988) Prog. Med. Chem. 25, 1-33
- 2. Sigal, N.H. & Dumont, F.J. (1992) Annu. Rev. Immunol. 10, 519-560.
- 3. Petit, G.R., Clewlow, P.J., Defresne, C., Doubeck, D.L., Cerny, R.L. & Rutzler, K. (1990) Can. J.Chem. 68, 708-711
- 4. Cebrat, M., Wieczorek, Z. & Siemion, I.Z. (1996) Peptides 17, 191-196.
- 5. Konat, R.K., Mierke, D.F., Kessler, H., Kutscher, B., Bernd, M. & Voegeli, R. (1993) Helv. Chim. Acta76, 1649-1666
- 6. Marshall, G.R., Humblet, C., Van Opdenbosch, N. & Zabrocki, J. (1981) in: Peptides: Synthesis,Structure and Function, Proc. 7th Am. Pept. Symp. (Rich, D. & Gross, E., eds.) pp. 669-672, PierceChemical Co., Rockford IL
- 7. Yu, K.L. & Johnson, R.L. (1987) J. Org. Chem. 52, 2051-2059.
- 8. Zabrocki, J., Smith, G. D., Dunbar, J.B., Jr., Iijima, H. & Marshall, G.R. (1988) J. Am. Chem. Soc. 110, 5875-5880.
- 9. Zabrocki, J., Dunbar, J.B., Jr., Marshall, K.W., Toth, M.V. & Marshall, G.R. (1992) J. Org. Chem. 57, 202-209.
- 10. Smith, G.D., Zabrocki, J., Flak, T.A. & Marshall, G.R. (1991) Int. J. Pept. Protein Res. 37, 191-197.
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Publication order reference
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bwmeta1.element.bwnjournal-article-abpv48i4p1151kz