Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

• Authors: Paweł Zubrzak , Karol Kociołek , Marek Smoluch , Jerzy Silberring , Marek L Kowalski , Barbara Szkudlińska , Janusz Zabrocki
• Languages of publication: EN

Abstracts

EN

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

Keywords

EN

immunosuppression; cis-amide bond; 1,5-disubstituted tetrazole ring; hymenistatin I

• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1151-1154

Dates

published

2001

received

2001-09-19

accepted

2001-12-7

Contributors

author

Paweł Zubrzak

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

author

Karol Kociołek

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

author

Marek Smoluch

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

author

Jerzy Silberring

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

author

Marek L Kowalski

• Department of Immunology, Medical University of Łódź, Łódź, Poland

author

Barbara Szkudlińska

• Department of Immunology, Medical University of Łódź, Łódź, Poland

author

Janusz Zabrocki

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

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