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2001 | 48 | 4 | 1147-1150
Article title

Design, synthesis and biological evaluation of a new bridged immunosuppressor.

Content
Title variants
Languages of publication
EN
Abstracts
EN
A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-γ-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
Year
Volume
48
Issue
4
Pages
1147-1150
Physical description
Dates
published
2001
received
2001-10-19
accepted
2001-11-13
References
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  • 2. Szewczuk, Z., Wieczorek, Z., Stefanowicz, P., Wilczynski, A. & Siemion, I.Z. (1997) Arch. Immunol. Exp. Ther.(Warsz) 45, 335-341.
  • 3. Szewczuk, Z., Stefanowicz, P., Wilczyński, A., Siemion, I.Z., Cierniewski, C.S., Kralisz, U. & Wieczorek, Z. (1996) Biopolymers 40, 571-583.
  • 4. Szewczuk, Z., Wilczyński, A., Dyba, M., Petry, I, Siemion, I.Z. & Wieczorek, Z. (2000) Peptides 21, 1849-1858.
  • 5. Szewczuk, Z., Buczek, P., Stefanowicz, P., Krajewski, K., Siemion, I.Z. & Wieczorek, Z. (2001) Acta Biochim. Polon. 48, 121-130.
  • 6. Cammarota, G., Scheirle, A.T.B., Doran, D.M., Knorr, R., Bannwarth, W., Guardiola, J. & Sinigaglia, F. (1992) Nature 356, 799-801.
  • 7. Zagury, J.F., Bernard, J., Achour, A., Astgen, A., Lachgar, A., Fall, L., Carelli, C., Issing, W., Mbika, J.P., Picard, O., Carlotti, M., Callebaut, I., Mornon, J.P., Burny, A., Feldman, M., Bizzini, B. & Zagury, D. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7573-7577.
  • 8. Szewczuk, Z., Wilczyński, A., Stefanowicz, P., Fedorowicz, W., Siemion, I.Z. & Wieczorek, Z. (1999) Mol. Immunol. 36, 525-533.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i4p1147kz
Identifiers
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