Design, synthesis and biological evaluation of a new bridged immunosuppressor.

• Authors: Zbigniew Szewczuk , Andrzej Wilczyński , Inga Petry , Ignacy Z Siemion , Zbigniew Wieczorek
• Languages of publication: EN

Abstracts

EN

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-γ-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

Keywords

EN

chemical synthesis; MS-MS sequencing; histocompatibility antigen; bridged analog; HLA-DQ; RGD-sequence; MHC class-II

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1147-1150

Dates

published

2001

received

2001-10-19

accepted

2001-11-13

Contributors

author

Zbigniew Szewczuk

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Andrzej Wilczyński

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Inga Petry

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Ignacy Z Siemion

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Zbigniew Wieczorek

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

References

• 1. Szewczuk, Z., Siemion, I.Z. & Wieczorek, Z. (1996) Mol. Immunol. 33, 903-908.
• 2. Szewczuk, Z., Wieczorek, Z., Stefanowicz, P., Wilczynski, A. & Siemion, I.Z. (1997) Arch. Immunol. Exp. Ther.(Warsz) 45, 335-341.
• 3. Szewczuk, Z., Stefanowicz, P., Wilczyński, A., Siemion, I.Z., Cierniewski, C.S., Kralisz, U. & Wieczorek, Z. (1996) Biopolymers 40, 571-583.
• 4. Szewczuk, Z., Wilczyński, A., Dyba, M., Petry, I, Siemion, I.Z. & Wieczorek, Z. (2000) Peptides 21, 1849-1858.
• 5. Szewczuk, Z., Buczek, P., Stefanowicz, P., Krajewski, K., Siemion, I.Z. & Wieczorek, Z. (2001) Acta Biochim. Polon. 48, 121-130.
• 6. Cammarota, G., Scheirle, A.T.B., Doran, D.M., Knorr, R., Bannwarth, W., Guardiola, J. & Sinigaglia, F. (1992) Nature 356, 799-801.
• 7. Zagury, J.F., Bernard, J., Achour, A., Astgen, A., Lachgar, A., Fall, L., Carelli, C., Issing, W., Mbika, J.P., Picard, O., Carlotti, M., Callebaut, I., Mornon, J.P., Burny, A., Feldman, M., Bizzini, B. & Zagury, D. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7573-7577.
• 8. Szewczuk, Z., Wilczyński, A., Stefanowicz, P., Fedorowicz, W., Siemion, I.Z. & Wieczorek, Z. (1999) Mol. Immunol. 36, 525-533.