Design, synthesis and biological evaluation of a new bridged immunosuppressor.

• Authors: Zbigniew Szewczuk , Andrzej Wilczyński , Inga Petry , Ignacy Z Siemion , Zbigniew Wieczorek
• Languages of publication: EN

Abstracts

EN

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-γ-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

Keywords

EN

chemical synthesis; MS-MS sequencing; histocompatibility antigen; bridged analog; HLA-DQ; RGD-sequence; MHC class-II

• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1147-1150

Dates

published

2001

received

2001-10-19

accepted

2001-11-13

Contributors

author

Zbigniew Szewczuk

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Andrzej Wilczyński

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Inga Petry

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Ignacy Z Siemion

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Zbigniew Wieczorek

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

References

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