Evolutionary principles for generating protein mimetics: Directed assembly of peptide loops on topological templates.

• Authors: Damiano Banfi , Bhubaneswar Mandal , Manfred Mutter , Luc Patiny
• Languages of publication: EN

Abstracts

EN

A novel methodology for the reversible competitive condensation of peptide loops to chemoreactive topological templates is presented.

Keywords

EN

combinatorial chemistry; topological templates; protein mimicry; protein mimetics

• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1105-1107

Dates

published

2001

received

2001-09-19

accepted

2001-11-03

Contributors

author

Damiano Banfi

• Institute of Organic Chemistry, University of Lausanne, ,BCH-Dorigny, CH-1015 Lausanne, Switzerland

author

Bhubaneswar Mandal

• Institute of Organic Chemistry, University of Lausanne, ,BCH-Dorigny, CH-1015 Lausanne, Switzerland

author

Manfred Mutter

• Institute of Organic Chemistry, University of Lausanne, ,BCH-Dorigny, CH-1015 Lausanne, Switzerland

author

Luc Patiny

• Institute of Organic Chemistry, University of Lausanne, ,BCH-Dorigny, CH-1015 Lausanne, Switzerland

References

• 1. Tuchscherer, G., Grell, D., Mathieu, M. & Mutter, M. (1999) J. Pept. Res. 54, 185-194.
• 2. Tuchscherer, G., Scheibler, L., Dumy, P. & Mutter, M. (1998) Biopolymers 47, 63-73.
• 3. Sila, U. & Mutter, M. (1995) J. Mol. Recognit. 8, 29-34.
• 4. Mutter, M., Dumy, P., Garrouste, P., Lehmann, C., Mathieu, M., Peluso, S., Razaname, A. & Tuchscherer, G. (1996) Angew. Chem. Int. Ed. Engl 35, 1482-1485.