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2001 | 48 | 4 | 1051-1060
Article title

The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture.

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EN
Abstracts
EN
Monomeric (G), total (T) and filamentous (F) actin and the state of actin polymerisation (F:G) were determined and actin filaments were visualized in hepatoma Morris 5123 cells cultured in the presence of methotrexate (MTX) at various concentration. The exposure of the cells to this drug resulted in a decrease of total and polymerised actin in cytoplasm and in some changes in actin filament organization. This coincided with a decrease of the cells' ability to migrate through Matrigel coated filters and with inhibition of tumour formation after reimplantation of the methotrexate treated cells to experimental rats.
Year
Volume
48
Issue
4
Pages
1051-1060
Physical description
Dates
published
2001
received
2001-11-6
accepted
2001-12-4
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i4p1051kz
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