Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion.

• Authors: Bozenna Rempola , Aneta Kaniak , Jean-Paul di Rago , Joanna Rytka
• Languages of publication: EN

Abstracts

EN

Saccharomyces cerevisiae homologues of phosphotyrosyl phosphatase activator(PTPA) are encoded by RRD1 and RRD2, genes whose combined deletion is synthetic lethal. Previously we have shown that the lethality of rrd1,2Δ can be suppressed by increasing the osmolarity of the medium. Here we show that the lethality of rrd1,2Δ is also suppressed under oxygen-limited conditions. The absence of respiration per se is not responsible for the suppression since elimination of the mitochondrial genome or a block in heme biosynthesis fail to rescue the rrd1,2Δ double mutation.

Keywords

EN

conditional lethality; phosphotyrosyl phosphatase activator (PTPA); anaerobiosis; Saccharomyces cerevisiae

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1043-1049

Dates

published

2001

received

2001-10-15

accepted

2001-12-6

Contributors

author

Bozenna Rempola

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

author

Aneta Kaniak

• Department of Genetics, Washington University Medical School, St. Louis, U.S.A.

author

Jean-Paul di Rago

• Institut de Biochimie et Génétique Cellulaire, CNRS, Bordeaux, France

author

Joanna Rytka

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

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