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2001 | 48 | 3 | 615-622
Article title

An introduction to DNA chips: principles, technology, applications and analysis.

Content
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EN
Abstracts
EN
This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene's expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.
Publisher

Year
Volume
48
Issue
3
Pages
615-622
Physical description
Dates
published
2001
received
2001-04-3
revised
2001-09-4
accepted
2001-09-5
Contributors
  • Department of Biotechnology, Royal Institute of Technology, Stockholm, Sweden
  • Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i3p615kz
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