Background level of 8-oxo-2'-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.

• Authors: Daniel Gackowski , Marek Ciecierski , Arkadiusz Jawień , Ryszard Oliński
• Languages of publication: EN

Abstracts

EN

Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.

Keywords

EN

α-tocopherol; ascorbic acid; retinol; 8-oxo-2'-deoxyguanosine

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 2
• Pages: 535-539

Dates

published

2001

received

2001-02-14

revised

2001-03-30

accepted

2001-04-30

Contributors

author

Daniel Gackowski

• Department of Clinical Biochemistry, The Ludwik Rydygier Medical University, M. Karłowicza 24, 85-092 Bydgoszcz, Poland

author

Marek Ciecierski

• Department and Clinic of Surgery, The Ludwik Rydygier Medical University, M. Karłowicza 24, 85-092 Bydgoszcz, Poland

author

Arkadiusz Jawień

• Department and Clinic of Surgery, The Ludwik Rydygier Medical University, M. Karłowicza 24, 85-092 Bydgoszcz, Poland

author

Ryszard Oliński

• Department of Clinical Biochemistry, The Ludwik Rydygier Medical University, M. Karłowicza 24, 85-092 Bydgoszcz, Poland

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