The left-handed double helical nucleic acids.

• Authors: Bernard A Brown II , Alexander Rich
• Languages of publication: EN

Abstracts

EN

The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.

Keywords

EN

Zα; Z-RNA; Z-DNA; RNA editing; hypermutation; ADAR1

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 2
• Pages: 295-312

Dates

published

2001

received

2001-02-28

Contributors

author

Bernard A Brown II

• Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, U.S.A.

author

Alexander Rich

• Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, U.S.A.

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