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Abstracts
Cholesterol, an integral component of membranes in Eucaryota, is a modifier of membrane properties. In vivo studies have demonstrated that cholesterol can also modulate activities of some G protein-coupled receptors (GPCRs), which are integral membrane proteins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholesterol with the receptor, as recently demonstrated for the cholecystokinin type β (CCKRβ) or the oxytocin receptor (OTR). Using molecular modelling, we studied conformational preferences of cholesterol and several of its analogues. Subsequently, we simulated the distributions of their preferred conformations around the surface of OTR, CCKRβ and a chimeric oxytocin/cholecystokinin receptor. Consequently, we suggest residues on the surface of OTR which are potentially significant in the OTR/cholesterol interaction.
Journal
Year
Volume
Issue
Pages
83-93
Physical description
Dates
published
2001
received
2000-11-2
revised
2001-02-1
accepted
2001-02-20
Contributors
author
- Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
author
- Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
author
- Institute of Biochemistry, Johannes-Gutenberg-University, Mainz, Germany
author
- Institute of Biochemistry, Johannes-Gutenberg-University, Mainz, Germany
author
- Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
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Document Type
Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i1p83kz