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2001 | 48 | 1 | 83-93
Article title

Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor.

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Abstracts
EN
Cholesterol, an integral component of membranes in Eucaryota, is a modifier of membrane properties. In vivo studies have demonstrated that cholesterol can also modulate activities of some G protein-coupled receptors (GPCRs), which are integral membrane proteins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholesterol with the receptor, as recently demonstrated for the cholecystokinin type β (CCKRβ) or the oxytocin receptor (OTR). Using molecular modelling, we studied conformational preferences of cholesterol and several of its analogues. Subsequently, we simulated the distributions of their preferred conformations around the surface of OTR, CCKRβ and a chimeric oxytocin/cholecystokinin receptor. Consequently, we suggest residues on the surface of OTR which are potentially significant in the OTR/cholesterol interaction.
Publisher

Year
Volume
48
Issue
1
Pages
83-93
Physical description
Dates
published
2001
received
2000-11-2
revised
2001-02-1
accepted
2001-02-20
Contributors
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Institute of Biochemistry, Johannes-Gutenberg-University, Mainz, Germany
  • Institute of Biochemistry, Johannes-Gutenberg-University, Mainz, Germany
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i1p83kz
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