Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

• Authors: Agnieszka Drzewiecka , Krystyna Urbańska , Zenon Matuszak , Marta Pineiro , Luis G Arnaut , Jan Habdas , Alicja Ratuszna , Grażyna Stochel
• Languages of publication: EN

Abstracts

EN

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Keywords

EN

melanoma; porphyrins; photodynamic therapy

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 1
• Pages: 277-282

Dates

published

2001

received

2000-10-25

revised

2001-02-28

accepted

2001-03-1

Contributors

author

Agnieszka Drzewiecka

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

author

Krystyna Urbańska

• Institute of Molecular Biology, Jagiellonian University, Kraków, Poland

author

Zenon Matuszak

• Institute of Molecular Biology, Jagiellonian University, Kraków, Poland

author

Marta Pineiro

• Department of Chemistry, University of Coimbra, Coimbra, Portugal

author

Luis G Arnaut

• Department of Chemistry, University of Coimbra, Coimbra, Portugal

author

Jan Habdas

• Institute of Chemistry, University of Silesia, Katowice, Poland

author

Alicja Ratuszna

• Institute of Physics, University of Silesia, Katowice, Poland

author

Grażyna Stochel

• Faculty of Chemistry, Jagiellonian University, Kraków, Poland

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