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2001 | 48 | 1 | 277-282
Article title

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

Content
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EN
Abstracts
EN
We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
Publisher

Year
Volume
48
Issue
1
Pages
277-282
Physical description
Dates
published
2001
received
2000-10-25
revised
2001-02-28
accepted
2001-03-1
Contributors
  • Faculty of Chemistry, Jagiellonian University, Kraków, Poland
  • Institute of Molecular Biology, Jagiellonian University, Kraków, Poland
  • Institute of Molecular Biology, Jagiellonian University, Kraków, Poland
author
  • Department of Chemistry, University of Coimbra, Coimbra, Portugal
author
  • Department of Chemistry, University of Coimbra, Coimbra, Portugal
author
  • Institute of Chemistry, University of Silesia, Katowice, Poland
  • Institute of Physics, University of Silesia, Katowice, Poland
  • Faculty of Chemistry, Jagiellonian University, Kraków, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i1p277kz
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