Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms.

• Authors: Svitlana Rybalko , Nadiya Nesterova , Svitlana Diadiun , Grygori Danylenko , Valentyna Danylenko , Svitlana Guzhova , Yuri Maksimov , Viatcheslav Arkadiev , Naila Ivans'ka , Olena Maksymenok , Nina Vrnycianu , Ella Zhtrebtsova , Tanya Grygoreva
• Languages of publication: EN

Abstracts

EN

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

Keywords

EN

N-polyvinylpyrrolidone-acrylic acid copolymers; anti-viral therapy; adamantane derivatives

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 1
• Pages: 241-249

Dates

published

2001

received

1999-10-25

revised

2000-05-7

accepted

2001-01-10

Contributors

author

Svitlana Rybalko

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Nadiya Nesterova

• Danylo Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

author

Svitlana Diadiun

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Grygori Danylenko

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Valentyna Danylenko

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Svitlana Guzhova

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Yuri Maksimov

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Viatcheslav Arkadiev

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Naila Ivans'ka

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Olena Maksymenok

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Nina Vrnycianu

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Ella Zhtrebtsova

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

author

Tanya Grygoreva

• Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv, Ukraine

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