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2001 | 48 | 1 | 137-144
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Intracellular potassium and chloride channels: An update.

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Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels.
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  • Abe, M.K., Kuo, W.L., Hershenson, M.B. & Rosner, M.R. (1999) Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol. Cell. Biol. 19, 1301-1312.
  • Ahmet, I., Sawa, Y., Nishimura, M., Kitakaze, M. & Matsuda, H. (2000) Cardioprotective effect of diadenosine tetraphosphate (AP4A) preservation in hypothermic storage and its relation with mitochondrial ATP-sensitive potassium channels. Transplantation 69, 16-20.
  • Al-Awqati, Q., Barasch, J. & Landry, D. (1992) Chloride channels of intracellular organelles and their potential role in cystic fibrosis. J. Exp. Biol. 172, 245-266.
  • Baines, C.P., Cohen, M.V. & Downey, J.M. (1999) Signal transduction in ischemic preconditioning: The role of kinases and mitochondrial K(ATP) channels. J. Cardiovasc. Electrophysiol. 10, 741-754.
  • Bernardi, P. (1999) Mitochondrial transport of cations: Channels, exchangers, and permeability transition. Physiol. Rev. 79, 1127-1155.
  • Berryman, M. & Bretscher, A. (2000) Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol. Biol. Cell. 11, 1509-1521.
  • Carroll, R. & Yellon, D.M. (2000) Delayed cardioprotection in a human cardiomyocyte-derived cell line: The role of adenosine, p38MAP kinase and the mitochondrial KATP. Basic Res. Cardiol. 95, 243-249.
  • Chuang, J., Milner, T.A., Zhu, M. & Sung, C. (1999) A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. J. Neurosci. 19, 2919-2928.
  • Dębska, G., May, R., Kicińska, A., Szewczyk, A., Elger, C. & Kunz, W. (2001) Potassium channel openers depolarise hippocampal mitochondria. Brain Res. 892, 42-50.
  • Dowland, L.K., Luyckx, V.A., Enck, A.H., Leclercq, B. & Yu, A.S. (2000) Molecular cloning and characterization of an intracellular chloride channel in the proximal tubule cell line, LLC-PK1. J. Biol. Chem. 275, 37765-37773.
  • Downey, J.M. & Cohen, M.V. (2000) Do mitochondrial K(ATP) channels serve as triggers rather than end-effectors of ischemic preconditioning. Basic Res. Cardiol. 95, 272-274.
  • Duncan, R.R., Westwood, P.K., Boyd, A. & Ashley, R.H. (1997) Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum. J. Biol. Chem. 272, 23880-23886.
  • Fernández-Salas, E., Sagar, M., Cheng, C., Yuspa, S.H. & Weinberg, W.C. (1999) p53 and tumor necrosis factor regulate the expression of a mitochondrial chloride channel protein. J. Biol. Chem. 274, 36488-36497.
  • Franco-Obregon, A., Wang, H.W. & Clapham, D.E. (2000) Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophys. J. 79, 202-214.
  • Fryer, R.M., Eells, J.T., Hsu, A.K., Henry, M.M. & Gross, G.J. (2000) Ischemic preconditioning in rats: Role of mitochondrial K(ATP) channel in preservation of mitochondrial function. Am. J. Physiol. Heart Circ. Physiol. 278, H305-H312.
  • Garlid, K.D. (2000) Opening mitochondrial K(ATP) in the heart what happens, and what does not happen. Basic Res. Cardiol. 95, 275-279.
  • Garlid, K.D., Paucek, P., Yarov-Yarovoy, V., Murray, H.N., Darbenzio, R.B., D'Alonzo, A.J., Lodge, N.J. Smith, M.A. & Grover, G.J. (1997) Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ. Res. 81, 1072-1082.
  • Ghosh, S., Standen, N.B. & Galinanes, M. (2000) Evidence for mitochondrial KATP channels as effectors of human myocardial preconditioning. Cardiovasc. Res. 45, 934-940.
  • Giovannucci, D.R., Hlubek, M.D. & Stuenkel, E.L. (1999) Mitochondria regulate the Ca2+-exocytosis relationship of bovine adrenal chromaffin cells. J. Neurosci. 19, 9261-9270.
  • Gross, G.J. (2000) The role of mitochondrial KATP channels in cardioprotection. Basic Res. Cardiol. 95, 280-284.
  • Gross, G.J. & Fryer, R.M. (1999) Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. Circ. Res. 84, 973-979.
  • Gunther, W., Luchow, A., Cluzeaud, F., Vandewalle, A. & Jentsch, T.J. (1998) ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc. Natl. Acad. Sci. U.S.A. 95, 8075-8080.
  • Inoue, I., Nagase, H., Kishi, K. & Higuti, T. (1991) ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature 352, 244-247.
  • Iwai, T., Tanonaka, K., Koshimizu, M. & Takeo, S. (2000) Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart. Br. J. Pharmacol. 129, 1219-1227.
  • Jakob, R., Bindokas, V. P. & Miller, R. J. (2000) Action of KATP channel openers on mitochondria in hippocampal neurons. Eur. J. Med. Res. 5, 41.
  • Jonas, E.A., Buchanan, J. & Kaczmarek, L.K. (1999) Prolonged activation of mitochondrial conductances during synaptic transmission. Science 286, 1347-1350.
  • Kevelaitis, E., Oubenaissa, A., Peynet, J., Mouas, C. & Menasche, P. (1999) Preconditioning by mitochondrial ATP-sensitive potassium channel openers: An effective approach for improving the preservation of heart transplants. Circulation 100, II345-II350.
  • Kicińska, A., Dębska, G., Kunz, W. & Szewczyk, A. (2000) Mitochondrial potassium and chloride channels. Acta Biochim. Polon. 47, 541-551.
  • Nishizawa, T., Nagao, T., Iwatsubo, T., Forte, J.G. & Urushidani, T. (2000) Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. J. Biol. Chem. 275, 11164- 11173.
  • O'Rourke, B. (2000) Pathophysiological and protective roles of mitochondrial ion channels. J. Physiol. 529, 23-36.
  • Paucek, P., Mironova, G., Mahdi, F., Beavis, A.D., Woldegiorgis, G. & Garlid, K.D. (1992) Reconstitution and partial purification of the glibenclamide- sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria. J. Biol. Chem. 267, 26062-26069.
  • Qian, Z., Okuhara, D., Abe, M.K. & Rosner, M.R. (1999) Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J. Biol. Chem. 274, 1621-1627.
  • Sasaki, N., Sato, T., Ohler, A., O'Rourke, B. & Marban, E. (2000) Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation 101, 439-445.
  • Sato, T. & Marban, E. (2000) The role of mitochondrial K(ATP) channels in cardioprotection. Basic Res. Cardiol. 95, 285-289.
  • Sato, T., Sasaki, N., O'Rourke, B. & Marban, E. (2000) Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J. Am. Coll. Cardiol. 35, 514-518.
  • Siemen, D., Loupatatzis, C., Borecky, J., Gulbins, E. & Lang, F. (1999) Ca2+-activated K channel of BK-type in inner mitochondrial membrane of a human glioma cell line. Biochem. Biophys. Res. Commun. 257, 549-554.
  • Szewczyk, A. (1998) The intracellular potassium and chloride channels: Properties, pharmacology and function. Mol Membr Biol. 15, 49-58.
  • Szewczyk, A. & Marban, E. (1999) Mitochondria: A new target for potassium channel openers? Trends Pharmacol. Sci. 20, 157-161.
  • Suzuki, M., Kotake, K., Fujikura, K., Inagaki, N., Suzuki, T., Gonoi, T., Seino, S. & Takata, K. (1997) Kir6.1: A possible subunit of ATP-sensitive K+ channels in mitochondria. Biochem. Biophys. Res. Commun. 241, 693-697.
  • Urushidani, T., Chow, D. & Forte, J.G. (1999) Redistribution of a 120 kDa phosphoprotein in the parietal cell associated with stimulation. J. Membr. Biol. 168, 209-220.
  • Yamamoto, K., Cox, J.P., Friedrich, T., Christie, P.T., Bald, M., Houtman, P.N., Lapsley, M.J., Patzer, L., Tsimaratos, M., Van't Hoff, W.G., Yamaoka, K., Jentsch, T.J. & Thakker, R.V.J. (2000) Characterization of renal chloride channel (CLCN5) mutations in Dent's disease. J Am. Soc. Nephrol. 11, 1460-1468.
  • Zhou, M., Tanaka, O., Sekiguchi, M., Sakabe, K., Anzai, M., Izumida, I., Inoue, T., Kawahara, K. & Abe, H. (1999) Localization of the ATP-sensitive potassium channel subunit (Kir6.1/uK(ATP)-1) in rat brain. Brain Res. Mol. Brain Res. 74, 15-25.
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