Motifs of the caldesmon family.

• Authors: Edward A Czuryło
• Languages of publication: EN

Abstracts

EN

Seven highly conserved regions were found in caldesmon molecules from various sources using the multiple sequence alignment method. Their localization coincides with regions where the binding sites to other proteins were postulated. Less conserved and highly divergent regions of the sequences are described as well. These results could refine the planning of caldesmon gene manipulations and accelerate the precise localization of binding sites in the caldesmon molecule and, as a consequence, this could help to elucidate its function in smooth muscle contraction.

Keywords

EN

secondary structure prediction; caldesmon; binding sites; conserved sequences; multiple sequence alignment

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 4
• Pages: 1019-1026

Dates

published

2000

received

2000-09-20

accepted

2000-11-15

revised

2000-11-2

Contributors

author

Edward A Czuryło

• Nencki Institute of Experimental Biology, Department of Muscle Biochemistry, Warszawa, Poland

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