Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.

• Authors: V E Kuz'min , V P Lozitsky , G L Kamalov , R N Lozitskaya , A I Zheltvay , A S Fedtchouk , D N Kryzhanovsky
• Languages of publication: EN

Abstracts

EN

Quantitative estimation of the structure - anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.

Keywords

EN

Schiff bases; macrocyclic pyridines

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 3
• Pages: 867-875

Dates

published

2000

received

1999-10-25

revised

2000-04-05

accepted

2000-05-05

Contributors

author

V E Kuz'min

• Odessa I.I. Mechnikov State University, Dvoryanskaya 2, Odessa, 65000 Odessa, Ukraine

author

V P Lozitsky

• Odessa I.I. Mechnikov Research Institute of Virology and Epidemiology, Odessa, Ukraine

author

G L Kamalov

• A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine

author

R N Lozitskaya

• A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine

author

A I Zheltvay

• A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine

author

A S Fedtchouk

• Odessa I.I. Mechnikov Research Institute of Virology and Epidemiology, Odessa, Ukraine

author

D N Kryzhanovsky

• A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine

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