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2000 | 47 | 3 | 867-875
Article title

Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.

Content
Title variants
Languages of publication
EN
Abstracts
EN
Quantitative estimation of the structure - anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.
Publisher

Year
Volume
47
Issue
3
Pages
867-875
Physical description
Dates
published
2000
received
1999-10-25
revised
2000-04-05
accepted
2000-05-05
Contributors
author
  • Odessa I.I. Mechnikov State University, Dvoryanskaya 2, Odessa, 65000 Odessa, Ukraine
author
  • Odessa I.I. Mechnikov Research Institute of Virology and Epidemiology, Odessa, Ukraine
author
  • A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine
  • A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine
author
  • A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine
author
  • Odessa I.I. Mechnikov Research Institute of Virology and Epidemiology, Odessa, Ukraine
  • A.V. Bogatsky Physical-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa, Ukraine
References
  • 1. Fenton, D.E. (1994) in Transition Metals in Supramolecular Chemistry (Fabbrizzi, L. & Poggi, A., eds.) 448, pp. 153-169, NATO ASI Series.
  • 2. Kamalov, G.L., Zakolodyazhnaya, O.V., Manolova, A.V., et al. (1992) Zhurnal Organicheskoy Khimii 62, 687-691.
  • 3. Monks, A., Scudicro, D.A., Skehan, P., et al. (1991) J. Natl. Cancer Inst. 83, 757-766.
  • 4. Kier, L. & Hall, K. (1976) Molecular Connectivity in Chemistry and Drug Research. Academic, N.Y.
  • 5. Chemical Applications of Topology and Graph Theory (1983) (King, R., ed.) Elsevier, Amsterdam-Oxford-New York-Tokyo.
  • 6. Pivina, T.S., Suhachev, D.V., Maslova, L.K., Shylapochnikov, V.A. & Zefirov, N.S. (1993) Dok. Akad. Nauk 330, 468-472.
  • 7. Hall, L.H., Mohmey, B., Kier, L.B. (1991) J. Chem. Inform. Comp. Sci. 31, 76-81.
  • 8. Bazak, S.C., Gieschem, D.P., Magnuson, V.R. & Harris, D.K. (1982) IRCS Med. Sci. 10, 619-628.
  • 9. Kramer, R.D. (1980) J. Amer. Chem. Soc. 102, 1837-1849.
  • 10. Kramer, R.D. (1980) J. Amer. Chem. Soc. 102, 1849-1859.
  • 11. Pollard, J.H. (1977) A Handbook of Numerical and Statistical Techniques. University Press, Cambridge.
  • 12. Gasteiger, I. (1980) Tetrahedron 36, 3219- 3288.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i3p867kz
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