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2000 | 47 | 3 | 815-819
Article title

Partial deglycosylation of α subunit modifies sturgeon gonadotropin function.

Content
Title variants
Languages of publication
EN
Abstracts
EN
Chemical deglycosylation (dg) of sturgeon Acipenser gueldenstaedti Br. (αGTH) resulted in the loss of 83% of its initial carbohydrate content. It altered also recombinant dgαGTH + βGTH dimer molecule, reducing its immunoreactivity by 30%, and fully blocking the hormonal function. CD spectroscopy showed that deglycosylation led to changes in the secondary structure of dgαGTH and in the α-β recombinant. The sugar moiety of sturgeon αGTH is suggested to play an important role in maintaining the biological function of the hormone dimer molecule.
Year
Volume
47
Issue
3
Pages
815-819
Physical description
Dates
published
2000
received
1999-11-24
revised
2000-04-26
accepted
2000-06-05
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i3p815kz
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