Alzheimer's disease: Its origin at the membrane, evidence and questions.

• Authors: Rene Buchet , Sławomir Pikuła
• Languages of publication: EN

Abstracts

EN

Numerous results on membrane lipid composition from different regions of autopsied Alzheimer's disease brains in comparison with corresponding fractions isolated from control brains revealed significant differences in serine- and ethanolamine-containing glycerophospholipid as well as in glycosphingolipid content. Changes in membrane lipid composition are frequently accompanied by alterations in membrane fluidity, hydrophobic mismatch, lipid signaling pathways, transient formation and disappearance of lipid microdomains, changes in membrane permeability to cations and variations of other membrane properties. In this review we focus on possible implications of altered membrane composition on β-amyloid precursor protein (APP) and on proteolysis of APP leading eventually to the formation of neurotoxic β-amyloid (Aβ) peptides, the major proteinaceous component of extracellular senile plaques, directly involved in Alzheimer's disease pathogenesis.

Keywords

EN

β-amyloid precursor protein; membrane proteases; Alzheimer's disease; lipid composition; membrane microdomains

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 3
• Pages: 725-733

Dates

published

2000

received

2000-07-04

accepted

2000-08-03

Contributors

author

Rene Buchet

• Laboratoire de Physico-Chimie Biologique, Université Claude Bernard-Lyon 1, UFR de Chimie-Biochimie, CNRS UMR 5013, F-69622 Villeurbanne, France

author

Sławomir Pikuła

• Department of Cellular Biochemistry, M. Nencki Institute of Experimental Biology, L. Pasteura 3, 02-093 Warszawa, Poland

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