Animal electricity, Ca2+ and muscle contraction. A brief history of muscle research

• Authors: Anthony N Martonosi
• Languages of publication: EN

Abstracts

EN

This brief review attempts to summarize some of the major phases of muscle research from Leeuwenhoek's description of sarcomeres in 1674, through Galvani's observation of "animal electricity" in 1791, to the discovery of Ca2+ as the key messenger in the coupling of nerve excitation to muscle contraction. The emerging molecular mechanism of the contraction process is one of the great achievements of biology, reflecting the intimate links between physics, chemistry and the life Sciences in the solution of biological problems.

Keywords

EN

cardiac and smooth muscles; skeletal; Ca2+; Mg-ATP; sarcoplasmic reticulum; contraction-relaxation cycle

• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 3
• Pages: 493-516

Dates

published

2000

received

2000-06-16

accepted

2000-07-20

Contributors

author

Anthony N Martonosi

• Department of Biochemistry and Molecular Biology, Health Science Center at Syracuse, State University of New York, 750 East Adams Street, Syracuse, NY 13210-2339, U.S.A.

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