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2000 | 47 | 2 | 481-486
Article title

QSARs of some novel isosteric heterocyclics with antifungal activity.

Content
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EN
Abstracts
EN
QSAR analysis of a set of previously synthesized 2,5,6-trisubstituted benzoxazole, benzimidazole and 2-substituted oxazolo(4,5-b)pyridine derivatives tested for growth inhibitory activity against Candida albicans, was performed by using the computer-assisted multiple regression procedure. The activity contributions for either heterocyclic ring systems or substituent effects of these compounds were determined from the correlation equation and the predictions for the lead optimization were described. The resulting QSAR revealed that the oxazolo(4,5-b)pyridine ring system with the substitution of a benzyl moiety at position 2 was the most favourable structure among the heterocyclic nuclei. Moreover, the fifth position in the fused ring system is found more significant than the other positions in improving the activity.
Publisher

Year
Volume
47
Issue
2
Pages
481-486
Physical description
Dates
published
2000
received
1999-10-25
accepted
2000-04-25
Contributors
  • Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, TR-06100 Tandogan Ankara-Turkey
author
  • Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, TR-06100 Tandogan Ankara-Turkey
author
  • Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, TR-06100 Tandogan Ankara-Turkey
  • Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, TR-06100 Tandogan Ankara-Turkey
References
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  • Mrozek, A., Trzezwinska, H., Karolak-Wojciechowska, J., Yalçìn, İ. & Ţener, E. (1999) Polish J. Chem. 73, 625-633.
  • Ören, İ. (1995) The synthesis, structure elucidation and quantitative structure-activity relationship analysis of some novel antimicrobial active isosteric heterocyclic compounds. Ph.D. Thesis, University of Ankara.
  • Ören, İ., Temiz, Ö., Yalçìn, İ., Şener, A. & Altanlar, N. (1998) Eur. J. Pharm. Sci. 7, 153-160.
  • Wold, S. (1991) Quant. Struct.-Act. Relat. 10, 191.
  • Yalçìn, İ., Ören, İ., Şener, E., Akìn, A. & Uçartürk, N. (1992) Eur. J. Med. Chem. 27, 401-406.
  • Yalçìn, İ., Şener, E., Özden, T., Özden, S. & Akìn, A. (1990) Eur. J. Med Chem. 25, 705-708.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i2p481kz
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