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2000 | 47 | 2 | 443-450
Article title

Detection of damage-recognition proteins from human lymphocytes.

Content
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EN
Abstracts
EN
Proteins recognizing and binding to damaged DNA (DDB-proteins) were analyzed in human lymphocytes obtained from healthy donors. Using an electrophoretic mobility shift assay several complexes between nuclear extract proteins and damaged DNA were detected: a complex specific for DNA damaged by N-acetoxy-N-acetylaminofluorene, another complex specific for UV-irradiated DNA, and two complexes specific for DNA damaged by cis-dichlorodiammine platinum. All the detected complexes differed in electrophoretic mobility and possibly contained different proteins. Complexes specific for free DNA ends were also detected in protein extracts from lymphocytes.
Publisher

Year
Volume
47
Issue
2
Pages
443-450
Physical description
Dates
published
2000
received
2000-01-17
accepted
2000-04-26
Contributors
  • Department of Experimental and Clinical Radiobiology, Center of Oncology, 44-100 Gliwice, Poland
author
  • Department of Experimental and Clinical Radiobiology, Center of Oncology, 44-100 Gliwice, Poland
  • Department of Experimental and Clinical Radiobiology, Center of Oncology, 44-100 Gliwice, Poland
author
  • Department of Experimental and Clinical Radiobiology, Center of Oncology, 44-100 Gliwice, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i2p443kz
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