Human diadenosine triphosphate hydrolase: Preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

• Authors: Aaron C Asensio , Carmen R Rodríguez-Ferrer , Sol Oaknin , Pedro Rotllán
• Languages of publication: EN

Abstracts

EN

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.

Keywords

EN

platelet; diadenosine 5',5'''- P1,P3-triphosphate; Fhit; diadenosine triphosphate hydrolase; tumour suppressor

• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 2
• Pages: 435-441

Dates

published

2000

received

1999-10-12

accepted

2000-04-20

Contributors

author

Aaron C Asensio

• Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain

author

Carmen R Rodríguez-Ferrer

• Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain

author

Sol Oaknin

• Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain

author

Pedro Rotllán

• Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain

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