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2000 | 47 | 2 | 393-412
Article title

Selectin glycoprotein ligands.

Content
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EN
Abstracts
EN
Lectin selectins and their counter-receptors participate in discontinuous cell-cell interactions concurrent with leukocyte tethering and rolling on endothelium, which, in consequence, leads to leukocyte penetration to lymphatic organs and generation of inflammation sites. Counter-receptors are glycoproteins in which carbohydrate units, the direct selectin ligands, are built into the polypeptide framework. In this review, the distribution, structure and function of the main ligands and counter-receptors for P-, L- and E-selectins known so far, have been discussed. The common biosynthetic pathway of sialyl-Lewis x and sulpho-sialyl-Lewis x determinants of selectin ligands has been described.
Year
Volume
47
Issue
2
Pages
393-412
Physical description
Dates
published
2000
received
1999-02-2
revised
2000-03-23
accepted
2000-05-10
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