Preferences help
enabled [disable] Abstract
Number of results
2000 | 47 | 2 | 393-412
Article title

Selectin glycoprotein ligands.

Title variants
Languages of publication
Lectin selectins and their counter-receptors participate in discontinuous cell-cell interactions concurrent with leukocyte tethering and rolling on endothelium, which, in consequence, leads to leukocyte penetration to lymphatic organs and generation of inflammation sites. Counter-receptors are glycoproteins in which carbohydrate units, the direct selectin ligands, are built into the polypeptide framework. In this review, the distribution, structure and function of the main ligands and counter-receptors for P-, L- and E-selectins known so far, have been discussed. The common biosynthetic pathway of sialyl-Lewis x and sulpho-sialyl-Lewis x determinants of selectin ligands has been described.
Physical description
  • Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland
  • Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland
  • Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland
  • 1. Hynes, R.O. & Lander, A.D. (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cell and axons. Cell 68, 303-322.
  • 2. Picker, L. & Butcher, E.C. (1992) Physiological and molecular mechanisms of lymphocyte homing. Annu. Rev. Immunol. 10, 561-591.
  • 3. Ley, K., Gaehtgens, P., Fennie, C., Singer, M. S., Lasky, L.A. & Rosen, S.D. (1991) Lecitin- like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo. Blood 77, 2553-2555.
  • 4. Von Andrian, U.H., Chambers, J.D., McEvoy, L.M., Bargatze, R.F., Arfors, K.E. & Butcher, E.C. (1991) Two-step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles of LECAM-1 and the leukocyte β2 integrins in vivo. Proc. Natl. Acad. Sci. U.S.A. 88, 7538-7542.
  • 5. Berg, E.L., Goldstein, L.A., Jutila, M.A., Nakache, M., Picker, L.J., Streeter, P.R., Wu, N.W., Zhou, D. & Butcher, E.C. (1989) Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic. Immunolog. Rev. 108, 5-18.
  • 6. Varki, A. (1994) Selectin ligands. Proc. Natl. Acad. Sci. U.S.A. 91, 7390-7397.
  • 7. Norgard-Sumnicht, K.E., Varki, N.M. & Varki, A. (1993) Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cell. Science 261, 480-483.
  • 8. Norgard-Sumnicht, K.E., Han, H., Powell, L., Kriegler, M., Varki, A. & Varki, N.M. (1993) Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acid. Proc. Natl. Acad. Sci. U.S.A. 90, 1068-1072.
  • 9. Watson, S.R., Imai, Y., Fennie, C., Geoffroy, J. S., Rosen, S.D. & Lasky, L.A. (1990) A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules. J. Cell. Biol. 110, 2221-2229.
  • 10. Tedder, T.F., Steeber, D.A., Chen, A. & Engel, P. (1995) The selectins: Vascular adhesion molecules. FASEB J. 9, 866-873.
  • 11. Bavilacqua, M.P. & Nelson, R.M. (1993) Selectins. J. Clin. Invest. 91, 379-387.
  • 12. Griffin, J.D., Spertini, O., Ernst, T.J., Belvin, M.P., Levine, H.B., Kanakura, Y. & Tedder, T.F. (1990) Granulocyte-macrophage colony- stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes and their precursors. J. Immunol. 145, 576-584.
  • 13. Boufanti, R., Furie, B.C. & Wagner, D.D. (1989) PADGEM (GMP 140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 73, 1109-1112.
  • 14. Sugama, Y., Tiruppathi, Ch., Janakidevi, K., Andersen, T.T., Fenton, J.W. & Malik, A.B. (1992) Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: A mechanism for stabilizing neutrophil adhesion. J. Cell Biol. 119, 935-944.
  • 15. Crocker, P.R. & Feizi, T. (1996) Carbohydrate recognition systems: Functional triads in cell-cell interactions. Curr. Opinion Struct. Biol. 6, 679-691.
  • 16. Kausas, G.S. (1996) Selectins and their ligands: Current concepts and controversies. Blood 88, 3259-3287.
  • 17. Rosen, S.D. & Bertozzi, C.R. (1994) The selectins and their ligands. Curr. Opinion Cell. Biol. 6, 663-673.
  • 18. Varki, A. (1997) Selectin ligands: Will the real ones please stand up? J. Clin. Invest. 99, 158-162.
  • 19. Duijvestijn, A.M., Horst, E., Pals, S.T., Rouse, B.N., Steere, A.C., Picker, L.J., Meijer, C.L.M. & Butcher, E.C. (1988) High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am. J. Pathol. 130, 147-155.
  • 20. Picker, L.J., Michie, S.A., Rott, L. & Butcher, E.C. (1990) A unique phenotype of skin-associated lymphocytes in humans. Am. J. Pathol. 136, 1053-1068.
  • 21. Berg, E.L., Robinson, M.K., Mansson, O., Butcher, E.C. & Magnani, J.L. (1991) A carbohydrate domain common to both sialyl Le a and sialyl Le x is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J. Biol. Chem. 266, 14869-14872.
  • 22. Mitsuoka, C., Kawakami-Kimura, N., Kasugai- Sawada, M., Hiraiwa, N., Toda, K., Ishida, H., Kiso, M., Hasegawa, A. & Kannagi, R. (1997) Sulfated sialyl Lewis x, the putative L-selectin ligand, detected on endothelial cells of high endothelial venules by a distinct set of anti-sialyl Lewis x antibodies. Biochem. Biophys. Res. Commun. 230, 546-551.
  • 23. Ohmori, K., Takada, A., Ohwaki, J., Takahashi, N., Yoshitaka, F., Michiyuki, M., Kiso, M., Hasegawa, A., Kannagi, M. & Kannagi, R. (1993) A distinct type of sialyl Lewis x antigen defined by a novel monoclonal antibody is selectively expressed on helper memory T cells. Blood 82, 2797-2805.
  • 24. Sawada, M., Takada, A., Ohwaki, I., Takahashi, N., Tateno, H., Sakamoto, J. & Kannangi, R. (1993) Specific expression of a complex sialyl Lewis x antigen on high endothelial venules of human lymph nodes: Possible candidate for L-selectin ligand. Biochem. Biophys. Res. Commun. 193, 337-347.
  • 25. Fukushima, K., Hirota, M., Terasaki, P.J., Wakisaka, A., Tagashi, H., Chia, D., Suyama, N., Fukushi, Y., Nudelman, E. & Hakomori, S. (1984) Characterization of sialosylated Lewis x as a new tumor-associated antigen. Cancer Res. 44, 5279-5285.
  • 26. Fukushi, Y., Nudelman, E.D., Levery, S.B., Rauvala, H. & Hakomori, S. (1984) Novel fucolipids accumulating in human adenocarcinoma. J. Biol. Chem. 259, 10511-10517.
  • 27. Fukushi, Y., Kannagi, R., Hakamori, S., Shepard, T., Kulander, B.G. & Singer, J.W. (1985) Localization and distribution of difucoganglioside (V13NeuAcV333Fuc2nLc6) in normal and tumor tissues defined by its monoclonal antibody FH6. Cancer Res. 45, 3711-3717.
  • 28. Hanski, C., Sheehan, J., Kiehntopf, M., Stolze, B., Stein, H. & Riecken, E.O. (1991) Increased number of accessible sugar epitopes defined with monoclonal antibody AM-3 on colonic mucins is associated with malignant transformation of colonic mucosa. Cancer Res. 51, 5342-5347.
  • 29. Muroi, K., Suda, T., Nojiri, H., Ema, H., Amemiya, Y., Miura, Y., Nakauchi, H., Singhal, A. & Hakamori, S. (1992) Reactivity profiles of leukemic myeloblasts with monoclonal antibodies directed to sialosyl-Le(x) and other lacto-series type 2 chain antigens: Absence of reactivity with normal hematopoietic progenitor cells. Blood 79, 713-719.
  • 30. Phillips, M.L., Nudelman, E.D., Gaeta, F.C.A., Perez, M., Singhal, A.K., Hakomori, S. & Paulson, J.C. (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Le x. Science 250, 1130-1132.
  • 31. Knapp, W., Majdic, O., Stockinger, H., Bettleheim, P., Liszka, K., Koller, U. & Peschel, C. (1984) Monoclonal antibodies to human myelomonocyte differentiation antigens in the diagnosis of acute myeloid leukemia. Med. Oncol. Tumor Pharmacother. 1, 257-262.
  • 32. Lowe, J.B., Kukowska-Latallo, J.F., Nair, R.P., Larsen, R.D., Marks, R.M., Macher, B.A., Kelly, R.J. & Ernst, L.K. (1991) Molecular cloning of a human fucosylotransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. J. Biol. Chem. 266, 17467- 17477.
  • 33. Magnani, J.L., Nilsson, B., Brockhaus, M., Zopf, D., Steplewski, Z., Koprowski, H. & Ginsburg, V. (1982) A monoclonal antibody- defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J. Biol. Chem. 257, 14365-144369.
  • 34. Streeter, P.R., Rouse, B.T.N. & Butcher, E.C. (1988) Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J. Cell. Biol. 107, 1853-1862.
  • 35. Hemmerich, S., Butcher, E.C. & Rosen, S.D. (1994) Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA79, an adhesion-blocking mAb. J. Exp. Med. 180, 2219-2226.
  • 36. Streeter, P.R., Berg, E.L., Rouse, B.N., Bargatze, R.F. & Butcher, E.C. (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature (London) 331, 41-46.
  • 37. Fina, L., Molgaard, H.V., Robertson, D., Bradley, N.J., Monaghan, P., Delia, D., Sutherland, D.R., Baker, M.A. & Greaves, M.F. (1990) Expression of the CD34 gene in vascular endothelial cells. Blood 75, 2417-2426.
  • 38. Moore, K.L., Patel, K.D., Bruehl, R.E., Li, F., Johnson, D.A., Lichenstein, H.S., Cummings, R.D., Bainton, D.F. & McEver, R.P. (1995) P-selectin glikoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J. Cell. Biol. 128, 661-671.
  • 39. Clark, R.A., Fuhlbrigge, R.C. & Springer, T.A. (1998) L-selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. J. Cell. Biol. 140, 721-731.
  • 40. Ito, K., Handa, K. & Hakomori, S.-J. (1994) Species-specific expression of sialosyl-Lex on polymorphonuclear leukocytes (PMN), in relation to selectin-dependent PMN responses. Glycoconjugate J. 11, 232-237.
  • 41. Miller, N., Vile, R.G. & Hart, J.R. (1996) Selectin ligands on human melanome cells. Glycoconjugate J. 13, 33-43.
  • 42. Foxall, C., Watson, S.R., Dowbenko, D., Fennie, Ch., Lasky, L.A., Kiso, M., Hasegawa, A., Asa, D. & Brandley, B.K. (1992) The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis x oligosaccharide. J. Cell Biol. 117, 895-902.
  • 43. Lowe, J.B. (1997) Selectin ligands, leukocyte trafficking, and fucosyltransferase genes. Kidney International 51, 1418-1426.
  • 44. Lowe, J.B. & Stoolman, L.M. (1996) Fucosyltransferase Fuc T-VII regulates E-selectin ligand synthesis in human T cells. J. Cell Biol. 133, 911-920.
  • 45. Maly, P., Thall, A.D., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H. & Lowe, J.B. (1996) The α(1,3) fucosyltransferase Fuc TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86, 643-653.
  • 46. Wagers, A.J., Stoolman, L.M., Kannagi, R., Craig, R. & Kansas, S. (1997) Expression of leukocyte fucosyltransferases regulates binding to E-selectin. J. Immunol. 159, 1917- 1929.
  • 47. Wagers, A.J., Lowe, J.B. & Kansas, G.S. (1996) An important role for the α1,3 fucosyltransferase, Fuc T-VII, in leukocyte adhesion to E-selectin. Blood 88, 2125-2132.
  • 48. Etzioni, A., Frydman, M., Pollack, S., Avidor, J., Phillips, M.L., Paulson, J.C. & Gershoni- Baruch, R. (1992) Recurrent severe infections caused by novel leukocyte adhesion deficiency. N. Eng. J. Med. 327, 1789-1792.
  • 49. Green, P.J., Tamatani, T., Watanabe, T., Miyasaka, M., Hasegawa, A., Kiso, M., Yuen, C.T., Stoll, M.S. & Feizi, T. (1992) High affinity binding of the leukocyte adhesion molecule L-selectin to 3'-sulphated-Le(a) and Le(x) oligosaccharides and the predominance of sulphate in this interaction demonstrated by binding studies with a series of lipid-linked oligosaccharides. Biochem. Biophys. Res. Commun. 188, 244-251.
  • 50. Suzuki, Y., Toda, Y., Tamatani, T., Watanabe, T., Suzuki, T., Nakao, T., Murase, K., Kiso, M., Hasegawa, A., Tadano-Aritomi, K., Ishizuka, J. & Miyasaka, M. (1993) Sulfated glycolipids are ligands for a lymphocyte homing receptor, L-selectin (LECAM-1). Binding epitope in sulfated sugar chain. Biochem. Biophys. Res. Commun. 190, 426-434.
  • 51. Nelson, R.M., Cecconi, O., Roberts, W.G., Aruffo, A., Linhardt, R.J. & Bevilacqua, M.P. (1993) Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 82, 3253-3258.
  • 52. Norgard-Sumnicht, K.E. & Varki, A. (1995) Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups. J. Biol. Chem. 270, 12012-12024.
  • 53. Giuffre, L., Cordey, A.S., Monai, N., Tardy, Y. & Schapira, M. (1997) Monocyte adhesion to activated aortic endothelium: Role of L-selectin and heparan sulfate proteoglycans. J. Cell Biol. 136, 945-956.
  • 54. McEver, R.P., Moore, K.L. & Cummings, R.D. (1995) Leukocyte trafficking mediated by selectin-carbohydrate interactions. J. Biol. Chem. 270, 11025-11028.
  • 55. Crottet, P., Kim, Y.J. & Varki, A. (1996) Subsete of sialylated, sulfated mucins of diverse orgins are recognized by L-selectin: Lack of evidence for unique oligosaccharide sequence mediating binding. Glycobiology 6, 191-208.
  • 56. Berg, E.L., Robinson, M.K., Warnock, R.A. & Butcher, E.C. (1991) The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J. Cell Biol. 114, 343-349.
  • 57. Michie, S.A., Streeter, P.R., Bolt, P.A., Butcher, E.C. & Picker, L.J. (1993) The human peripheral lymph node vascular addressin: An inducible endothelial antigen involved in lymphocyte homing. Am. J. Pathol. 143, 1688-1698.
  • 58. Imai, Y., Singer, M.S., Fennie, Ch., Lasky, L.A. & Rosen, S.D. (1991) Identification of carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J. Cell Biol. 113, 1213-1221.
  • 59. Imai, Y., True, D.D., Singer, M.S. & Rosen, S.D. (1990) Direct demonstration of lecitin activity of gp90, a lymphocyte homing receptor. J. Cell Biol. 111, 1225-1232.
  • 60. Lasky, L.A., Singer, M.S., Dowbenko, D., Imai, Y., Henzel, W.J., Grimley, C., Fennie, C., Gillett, N., Watson, S.R. & Rosen, S.D. (1992) An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell 69, 927-938.
  • 61. Kikuta, A. & Rosen, S.D. (1994) Localization of ligands for L-selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates. Blood 84, 3766-3775.
  • 62. Dowbenko, D., Kikuta, A., Fennie, C., Gillett, N. & Lasky, L.A. (1993) Glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk. J. Clin. Invest. 92, 952-960.
  • 63. Hemmerich, S. & Rosen, S.D. (1994) 6'-Sulfated sialyl Lewis x is a major capping group of GlyCAM1. Biochemistry 33, 4830-4835.
  • 64. Hemmerich, S., Leffler, H. & Rosen, S.D. (1995) Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J. Biol. Chem. 270, 12035-12047.
  • 65. Hemmerich, S., Bertozzi, C.R., Leffler, H. & Rosen, S.D. (1994) Identification of sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin. Biochemistry 33, 4820-4829.
  • 66. Tsuboi, S., Isogai, Y., Hada, N., King, J.K., Hindsgaul, O. & Fukuda, M. (1996) 6'Sulpho sialyl Lex but not 6sulpho sialyl Lex expressed on the cell surface supports L-selectin-mediated adhesion. J. Biol. Chem. 271, 27213- 27216.
  • 67. Hwang, S.T., Singer, M.S., Giblin, P.A., Yednock, T.A., Bacon, K.B., Simon, S.J. & Rosen, S.D. (1996) GlyCAM-1, a physiologic ligand for L-selectin, activates β2-integrins on naive peripheral lymphocytes. J. Exp. Med. 184, 1343-1348.
  • 68. Baumhueter, S., Singer, M.S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S.D. & Lasky, L.A. (1993) Binding of L-selectin to the vascular sialomucin CD34. Science 262, 436-438.
  • 69. Baumhueter, S., Dybdal, N., Kyle, C. & Lasky, L.A. (1994) Global vascular expression of murine CD 34, a sialomucin-like endothelial ligand for L-selectin. Blood 84, 2554-2564.
  • 70. Simmons, D.L., Satterthwaite, A.B., Tenen, D.G. & Seed, B. (1992) Molecular cloning of a cDNA encoding CD34, sialomucin of human hematopoietic stem cells. J. Immunol. 148, 267-271.
  • 71. Sutherland, D.R., Marsh, J.C.W., Davidson, J., Backer, M.A., Keating, A. & Mellors, A. (1992) Differential sensitivity of CD34 epitopes to cleavage by Pasteurella haemolytica glycoprotease: Implications for purification of CD34-positive progenitor cells. Exp. Hematol. 20, 590-599.
  • 72. Puri, K.D., Finger, E.B., Gaudernack, G. & Springer, T.A. (1995) Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. J. Cell Biol. 131, 261-270.
  • 73. Suzuki, A., Andrew, D.P., Gonzalo, J.A., Fukumoto, M., Spellberg, J., Hashiyama, M., Suda, T., Takimoto, H., Gerwin, N., Webb, J., Gutierrez-Ramos, J.-C., Molinex, G., McNiece, J., Ley, K., Butcher, E., May, W.S., Greaves, M.F., Amakawa, R., Tada, Y., Wakcham, A. & Mak, T.W. (1996) CD34 deficient mice have reduced eosinophil accumulation after allergen exposure and reveal a novel cross-reactive protein. Blood 87, 3550-3662.
  • 74. Berg, E.L., McEvoy, L.M., Berlin, C., Bargatze, R.F. & Butcher, E.C. (1993) L-Selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 366, 695-698.
  • 75. Butcher, E.C. & Picker, L.J. (1996) Lymphocyte homing and homeostasis. Science 272, 60-66.
  • 76. Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, J.L., Hamann, A. & Butcher, E.C. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM1. Cell 74, 185-195.
  • 77. Fuhlbrigge, R.C., Alon, R., Puri, K.D., Lowe, J.B. & Springer, T.A. (1996) Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. J. Cell Biol. 135, 837-848.
  • 78. Tu, L., Chen, A., Delahunty, M.D., Moore, K.L., Watston, S.R., McEver, R.P. & Tedder, T.F. (1996) L-Selectin binds to P-selectin glycoprotein ligand-1 on leukocytes. J. Immunol. 157, 3995-4004.
  • 79. Moore, K.L., Stults, N.L., Diaz, S., Smith, D.F., Cummings, R.D., Varki, A. & McEver, R.P. (1992) Identification of specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J. Cell Biol. 118, 445-456.
  • 80. Alon, R., Rossiter, H., Wang, X., Springer, T.A. & Kupper, T.S. (1994) Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. J. Cell Biol. 127, 1485-1495.
  • 81. Vachino, G., Chang, X.J., Veldman, G.M., Kumar, R., Sako, D., Fouser, L.A., Berndt, M.C. & Cumming, D.A. (1995) P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells. J. Biol. Chem. 270, 21966-21974.
  • 82. Sako, D., Chang, X.J., Barone, K.M., Vachino, G., White, H.M., Shaw, G., Veldman, G.M., Bean, K.B., Ahern, T.J., Furie, B., Cumming, D.A. & Larsen, G.A. (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75, 1179-1186.
  • 83. Sako, D., Comess, K.M., Barone, K.M., Camphausen, R.T., Cumming, D.A. & Shaw, G.D. (1995) A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell 83, 323-331.
  • 84. Pouyani, T. & Seed, B. (1995) PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell 83, 333-343.
  • 85. Wilkins, P.P., Moore, K.L., McEver, R.P. & Cummings, R.D. (1995) Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. J. Biol. Chem. 270, 22677-22680.
  • 86. Snapp, K.R., Ding, H., Atkins, K., Warnke, R., Luscinskas, F.W. & Kansas, G.S. (1998) A novel P-selectin glycoprotein ligand-1 (PSGL-1) monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin. Blood 91, 154-164.
  • 87. Moore, K.L., Eaton, S.F., Lyons, D.E., Lichenstein, H.S., Cummings, R.D. & McEver, R.P. (1994) The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. J. Biol. Chem. 269, 23318-23327.
  • 88. Kumar, R., Camphausen, R.T., Sullivan, F.X. & Cumming, D.A. (1996) Core 2 β1,6-N- acetyglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin. Blood 88, 3872-3879.
  • 89. Snapp, K.R., Craig, R., Herron, M., Nelson, R.D., Stoolman, L.M. & Kansas, G.S. (1998) Dimerization of P-selectin glycoprotein ligand 1 (PSGL-1) required for optimal recognition of P-selectin. J. Cell Biol. 142, 263-270.
  • 90. Norman, K.E., Moore, K.L., McEver, R.P. & Ley, K. (1995) Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1. Blood 86, 4417-4421.
  • 91. De Luca, M., Dunlop, L.C., Andrews, R.K., Flannery, J., Jr., Ettling, R., Cumming, D.A., Veldman, G.M. & Berndt, M.C. (1995) A novel cobra venom metalloproteinase, mocarhagin, cleaves a 10-amino acid peptide from the mature N-terminus of P-selectin glycoprotein receptor, PSGL-1, and abolishes P-selectin binding. J. Biol. Chem. 270, 26734-26737.
  • 92. Norgard, K.E., Moore, K.L., Diaz, S., Stults, N.L., Ushiyama, S., McEver, R.P., Cummings, R.D. & Varki, A. (1993) Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides. J. Biol. Chem. 268, 12764- 12774.
  • 93. Levinovitz, A., Mühlhoff, J., Isenmann, S. & Vestweber, D. (1993) Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells. J. Cell Biol. 121, 449-459.
  • 94. Lenter, M., Levinovitz, A., Isenmann, S. & Vestweber, D. (1994) Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells. J. Cell Biol. 125, 471-481.
  • 95. Jutila, M.A., Bargatze, R.F., Kurk, S., Warnock, R.A., Ehsani, N., Watston, S.R. & Walcheck, B. (1994) Cell surface P- and E-selectin support shear-dependent rolling of bovine gamma/delta T cells. J. Immunol. 153, 3917-3928.
  • 96. Moore, K.L. & Thompson, L.F. (1992) P-selectin (CD62) binds to subpopulations of human memory T lymphocytes and natural killer cells. Biochem. Biophys. Res. Commun. 186, 173-181.
  • 97. Postigo, A.A., Marazuela, M., Sanchez-Madrid, F. & De Landazuri, M.O. (1994) B lymphocyte binding to E- and P-selectins is mediated through the de novo expression of carbohydrates in vitro and in vivo activated human B cells. J. Clin. Invest. 94, 1585-1596.
  • 98. Picker, L.J., Treer, J.R., Ferguson-Darnell, B., Collins, P.A., Bergstresser, P.R. & Terstappen, L.W. (1993) Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J. Immunol. 150, 1122- 1136.
  • 99. Knibbs, R.N., Craig, R.A., Natsuka, S., Chang, A., Cameron, M., Lowe, J.B. & Stodman, L.M. (1996) The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. J. Cell Biol. 133, 911-920.
  • 100. Gelb, A.B., Smoller, B.R., Warnke, R.A. & Picker, L.J. (1993) Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA). Am. J. Pathol. 142, 1556- 1564.
  • 101. Picker, L.J., Martin, R.J., Trumble, A., Newman, L.S., Collins, P.A., Bergstresser, P.R. & Leung, D.Y. (1994) Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur. J. Immunol. 24, 1269-1277.
  • 102. Walchek, B., Watts, G. & Jutila, M.A. (1993) Bovine γ/δT cells bind E-selectin via a novel glycoprotein receptor: First characterization of a lymphocyte/E-selectin interaction in an animal model. J. Exp. Med. 178, 853-863.
  • 103. Steegmaier, M., Levinovitz, A., Isenmann, I., Borges, E., Leuter, M., Kocher, H.P., Kleuser, B. & Vestweber, D. (1995) The E-selectin ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature 373, 615-620.
  • 104. Burruss, L.W., Zuber, M.E., Lueddecke, B.A. & Olwin, B.B. (1992) Identification of a cysteine-rich receptor for fibroblast growth factors. Mol. Cell Biol. 12, 5600-5609.
  • 105. Stieber, A., Mourelatos, Z., Chen, Y.J., Le Douarin, N. & Gonatas, N.K. (1995) MG160, a membrane protein of the Golgi apparatus which is homologous to a fibroblast growth factor receptor and to a ligand for E-selectin, is found only in the Golgi apparatus and appears early in chicken embryo development. Exp. Cell Res. 219, 562-570.
  • 106. Vestweber, D. (1996) Ligand-specificity of the selectins. J. Cell Biochem. 61, 585-591.
  • 107. Patel, T.P., Goelz, S.E., Lobb, R.R. & Parekh, R.B. (1994) Isolation and characterization of natural protein-associated carbohydrate ligands for E-selectin. Biochemistry 33, 14815-14824.
  • 108. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L. & Butcher, E.C. (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66, 921-933.
  • 109. Li, F., Wilkins, P.P., Crawley, S., Weinstein, J., Cummings, R.D. & McEver, R.P. (1996) Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. J. Biol. Chem. 271, 3255-3264.
  • 110. Larsen, R.D., Ernst, L.K., Nair, R.P. & Lowe, J.B. (1990) Molecular cloning, sequence, and expression of a human GDP-L-fucose: β-D-galactoside-2-α-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc. Natl. Acad. Sci. U.S.A. 87, 6674-6678.
  • 111. Rouquier, S., Lowe, J.B., Kelly, R.J., Fertitta, A.L., Lennon, G.G. & Giorgi, D. (1995) Molecular cloning of a human genomic region containing the H blood group α(1,2) fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. J. Biol. Chem. 270, 4632-4639.
  • 112. Kukowska-Latallo, J.F., Larsen, R.D., Nair, R.P. & Lowe, J.B. (1990) A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group α(1,3/1,4)fucosyltransferase. Genes & Development 4, 1288-1303.
  • 113. Goelz, S.E., Hession, C., Goff, D., Griffiths, B., Tizard, R., Newman, B., ChiRosso, G. & Lobb, R. (1990) ELFT: A gene that directs the expression of an ELAM-1 ligand. Cell 63, 1349-1356.
  • 114. Kumar, R., Potvin, B., Muller, W.A. & Stanley, P. (1991) Cloning of a human α(1,3)fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. J. Biol. Chem. 266, 21777- 21783.
  • 115. Weston, B.W., Nair, R.P., Larsen, R.D. & Lowe, B. (1992) Isolation of a novel human α(1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group α(1,3/1,4)fucosyltransferase gene. J. Biol. Chem. 267, 4152-4160.
  • 116. Koszidin, K.L. & Bowen, B.R. (1992) The cloning and expression of human α1,3 fucosyltransferase capable of forming the E-selectin ligand. Biochem. Biophys. Res. Commun. 187, 152-157.
  • 117. Weston, B.W., Smith, P.L., Kelly, R.J. & Lowe, J.B. (1992) Molecular cloning of a fourth member of a human α(1,3)fucosyltransferase gene family. J. Biol. Chem. 267, 24575- 24584.
  • 118. Borsig, L., Katopodis, A.G., Bowen, B.R. & Berger, E.G. (1998) Trafficking and localization studies of recombinant α1,3 fucosyltransferase VI stably expressed in CHO cell. Glycobiology 8, 259-268.
  • 119. Larson, G., Boerjeson, C., Elmgren, A., Kernholt, A., Henry, S., Fletcher, A., Aziz, A., Mollicone, R. & Oriol, R. (1996) Identification of a new plasma α(1,3) fucosyltransferase (FUT6) allele requires an extended genotyping strategy. Vox Sang. 71, 233-241.
  • 120. Sasaki, K., Kurata, K., Funayama, K., Nagata, M., Watanabe, E., Ohta, S., Hanai, N. & Nishi, T. (1994) Expression cloning of a novel α1,3 fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. J. Biol. Chem. 269, 14730-14737.
  • 121. Natsuka, S., Gersten, K.M., Zenita, K., Kannagi, R. & Lowe, J.B. (1994) Molecular cloning of a cDNA encoding a novel human leukocyte α1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. J. Biol. Chem. 269, 16789-16794.
  • 122. Brinkman-Van der Linden, E.C.M., Mollicone, R., Oriol, R., Larson, G., Van den Eijnden, D.H. & Van Dijk, W. (1996) A missense mutation in the FUT6 gene results in total absence of α3-fucosylation of human α1-acid glycoprotein. J. Biol. Chem. 271, 14492-14495.
  • 123. Sasaki, K., Watanabe, E., Kawashima, K., Sekine, S., Dohi, T., Oshima, M., Hanai, N., Nishi, T. & Hasegawa, M. (1993) Expression cloning of a novel Galβ(1,3/1,4)GlcNAcα- 2,3-sialyltransferase using lectin resistance selection. J. Biol. Chem. 268, 22782-22787.
  • 124. Wen, D.X., Livingston, B.D., Medzihradszky, K.F., Kelm, S., Berlingame, A.L. & Paulson, J.C. (1992) Primary structure of Galβ1,3(4)GlcNAcα2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family. J. Biol. Chem. 267, 21011-21019.
  • 125. Kitagawa, H. & Paulson, J.C. (1993) Cloning and expression of human Galβ1,3(4)GlcNAcα2,3-sialyltransferase. Biochem. Biophys. Res. Commun. 194, 375-382.
  • 126. Gillespie, W., Kelm, S. & Paulson, J.C. (1992) Cloning and expression of the Galβ1,3 GalNAcα2,3-sialyltransferase. J. Biol. Chem. 267, 21004-21010.
  • 127. Kitagawa, H. & Paulson, J.C. (1994) Cloning of a novel α-2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. J. Biol. Chem. 269, 1394-1401.
  • 128. Crommie, D. & Rosen, S.D. (1995) Biosynthesis of GlyCAM-1a mucin-like ligand for L-selectin. J. Biol. Chem. 270, 22614-22624.
  • 129. Scudder, P.R., Shailubhai, K., Duffin, K.L., Streeter, P.R. & Jacob, G.S. (1994) Enzymatic synthesis of a 6'-sulphated sialyl-Lewis x which is an inhibitor of L-selectin binding to peripheral addressin. Glycobiology 4, 929- 933.
  • 130. Jain, R.K., Vig, R., Rampal, R., Chandrasekaran, E.V. & Matta, K.L. (1994) Total synthesis of 3'-O-sialyl, 6'O-sulfo Lewis x, NeuAcα2,3(6-O-SO3Na)Galβ1,4(Fucα1,3) GlcNAc-β-OMe: A major capping group of GlyCAM-1. J. Am. Chem. Soc. 116, 12123- 12124.
  • 131. Spiro, R.G. & Bhoyroo, U.D. (1998) Characterization of a spleen sulphotransferase responsible for the 6-O-sulphation of the galactose residue in sialyl-N-acetyl-lactosamine sequences. Biochem. J. 331, 265-271.
  • 132. Uchimura, K., Muramatsu, H., Kadomatsu, K., Fan, Q.W., Kurosawa, N., Mitsuoka, C., Kannagi, R., Habuchi, O. & Muramatsu, T. (1998) Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J. Biol. Chem. 273, 22577- 22583.
  • 133. Smith, P.L., Gersten, K.M., Petryniak, B., Kelly, R.J., Rogers, C., Natsuka, Y., Alford, J.A., Scheidegger, E.P., Natsuka, S. & Lowe, J.B. (1996) Expression of the α(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. J. Biol. Chem. 271, 8250-8259.
  • 134. Girard, J.P. & Amalric, F. (1998) Biosynthesis of sulfated L-selectin ligands in human high endothelial venules (HEV). Adv. Exp. Med. Biol. 435, 55-62.
  • 135. Britten, C.J., van den Eijnden, D.H., McDowell, W., Kelly, V.A., Witham, S.J., Edbrooke, M.R., Bird, M.I., deVries, T. & Smithers, N. (1998) Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: Role of FucT-VII in the generation of selectin ligands. Glycobiology 8, 321-327.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.