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2000 | 47 | 1 | 79-85

Article title

Biomimetic polyesters and their role in ion transport across cell membranes.

Content

Title variants

Languages of publication

EN

Abstracts

EN
Syntheses of biomimetic low-molecular weight poly-(R)-3-hydroxybutanoate mediated by three types of supramolecular catalysts are presented. The utility of these synthetic polyesters for preparation of artificial channels in phospholipid bilayers capable of sodium and calcium ion transport across cell membranes, is discussed. Further studies on possible applications of these bio-polymers for manufacturing drugs of prolonged activity are under way.

Year

Volume

47

Issue

1

Pages

79-85

Physical description

Dates

published
2000
received
1999-10-25

Contributors

  • Centre of Polymer Chemistry, Polish Academy of Sciences, 41-800 Zabrze, Poland
author
  • Centre of Polymer Chemistry, Polish Academy of Sciences, 41-800 Zabrze, Poland
  • Centre of Polymer Chemistry, Polish Academy of Sciences, 41-800 Zabrze, Poland
author
  • Centre of Polymer Chemistry, Polish Academy of Sciences, 41-800 Zabrze, Poland

References

  • 1. Reusch, R.N., Sparrow, A.W. & Gardiner, J. (1992) Transport of poly-β-hydroxybutyrate in human plasma. Biochim. Biophys. Acta 1123, 33-40.
  • 2. Seebach, D., Bürger, H.M., Müller, H.M., Lengweiler, U.D., Beck, A.K., Sykes, K.E., Barker, P.A. & Barcham, P.J. (1994) Synthesis of linear oligomers of (R)-3-hydroxybutyrate and solid-state structural investigations by electron microscopy and X-ray scattering. Helv. Chim. Acta 77, 1099-1123.
  • 3. Lengweiler, U.D., Fritz, M.G. & Seebach, D. (1996) 61. Synthese monodisperser Linearer und Cyclischer Oligomere der (R)-3-Hydroxybuttersure mit bis zu 128 Einheiten. Helv. Chim. Acta 79, 670-701.
  • 4. Gross, R.A., Zhang, Y., Konrad, G. & Lenz, R.W. (1988) Polymerization of β-monosubstituted-β-propiolactones using trialkylaluminum-water catalytic systems and polymer characterization. Macromolecules 21, 2657- 2668.
  • 5. Pajerski, A.D. & Lenz, R.W. (1993) Stereoregular polymerization of β-butyrolactone by aluminoxane catalysts. Makromol. Chem. Macromol. Symp. 73, 7-26.
  • 6. Zhang, Y., Gross, R.A. & Lenz, R.W. (1990) Stereochemistry of the ring-opening polymerization of (S)-β-butyrolactone. Macromolecules 23, 3206-3212.
  • 7. Abe, H., Matsubara, I., Doi, Y., Hori, Y. & Yamaguchi, A. (1994) Physical properties and enzymatic degradability of poly(3-hydroxybutyrate) stereoisomers with different stereoregularities. Macromolecules 27, 6018- 6025.
  • 8. Jedliński, Z., Kurcok, P., Kowalczuk, M. & Kasperczyk, J. (1986) Anionic polymerization of 4-methyl-2-oxetanone. Makromol. Chem. 187, 1651-1656.
  • 9. Weissberger, W. (1970) Organic Solvents. Wiley Int., New York, pp. 704.
  • 10. Jedliński, Z., Kurcok, P. & Kowalczuk, M. (1985) Polymerization of β-lactones initiated by potassium solutions. Macromolecules 18, 2679-2683.
  • 11. Jedliński, Z., Kurcok, P. & Lenz, R.W. (1998) First facile synthesis of biomimetic poly(R)-3-hydroxybutyric acid via regioselective anionic polymerization of (S) β-butyrolactone. Macromolecules 31, 6718-6720.
  • 12. Das, S., Kurcok, P., Jedliński, Z. & Reusch, R.N. (1999) Ion channels formed by biomimetic oligo-(R)-3-hydroxybutyrates and inorganic polyphosphates in planar lipid bilayers. Macromolecules 32, 8781-8785.
  • 13. Dye, J.L. (1979) Compounds with alkali metal anions. Angew. Chem. 91, 613-625.
  • 14. Edwards, P.P. (1981) The electronic properties of metal solutions. Phys. Chem. Liq. 10, 189-227.
  • 15. Jedliński, Z., Misiońek, A. & Kurcok, P. (1989) Enolate anions. 2. Reaction between potassium solutions containing crown ethers and β-lactones. J. Org. Chem. 54, 1500-1501.
  • 16. Jedliński, Z. & Kowalczuk, M. (1989) Nature of the active centers and propagation mechanism of the polymerization of β-propiolactones initiated by potassium anions. Macromolecules 22, 3242-3244.
  • 17. Jedliński, Z. (1996) Polyesters; in Polymeric Materials Encyclopedia (Salomon, J.C., ed.) vol.8, pp. 5897-5902, CRC Press, Boca Raton.
  • 18. Reusch, R.N. (1989) Poly-β-hydroxybutyrate/ calcium polyphosphate complexes in eukaryotic membranes. Proc. Soc. Exp. Biol. Med. 191, 377-381.
  • 19. Jedliński, Z., Kowalczuk, M., Adamus, G., Sikorska, W. & Rydz, J. (1999) Novel synthesis of functionalized poly(3-hydroxybutanoic acid) and its copolymers. Int. J. Biol. Macromol. 25, 247-253.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv47i1p79kz
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