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2000 | 47 | 1 | 59-64
Article title

Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

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Abstracts
EN
We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the neccessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.
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Year
Volume
47
Issue
1
Pages
59-64
Physical description
Dates
published
2000
received
1999-10-25
Contributors
  • Medical Research Center, Polish Academy of Sciences, 02-106, Warszawa, Poland
author
  • Medical Research Center, Polish Academy of Sciences, 02-106, Warszawa, Poland
author
  • Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland
  • Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland
  • Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland
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Publication order reference
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bwmeta1.element.bwnjournal-article-abpv47i1p59kz
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