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2000 | 47 | 1 | 157-164
Article title

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

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A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

Physical description
  • European Laboratory Association Section Ibbenbüren, Ibbenbüren, Germany
  • Faculty of Chemistry, Univeristy of Gdańsk, Gdańsk, Poland
  • Molecular Diagnostics Division, Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
  • Institute of Pathology, Osnabrück, Germany
  • Department of Obstetrics/Gynecology, St. Elisabeth Hospital, Ibbenbüren, Germany
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