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2000 | 47 | 1 | 149-156
Article title

c-myc Oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer.

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EN
Abstracts
EN
A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations.
Publisher

Year
Volume
47
Issue
1
Pages
149-156
Physical description
Dates
published
2000
received
1999-10-25
Contributors
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Department of Obstetrics/Gynecology, St. Elisabeth Hospital, Ibbenbüren, Germany
author
  • Institute of Pathology, Osnabrück, Germany
  • Molecular Diagnostics Division, Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
author
  • European Laboratory Association Section Ibbenbüren, Ibbenbüren, Germany
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i1p149kz
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