Comparative studies on cell stimulatory, permeabilizing and toxic effects induced in sensitive and multidrug resistant fungal strains by amphotericin B (AMB) and N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME).

• Authors: Joanna Szlinder-Richert , Barbara Cybulska , Jolanta Grzybowska , Edward Borowski , Rajendra Prasad
• Languages of publication: EN

Abstracts

EN

N-Methyl-N-D-fructosyl-amphotericin B methyl ester (MFAME) is a new derivative of amphotericin B, which is characterised by low toxicity to mammalian cells and good solubility in water of its salts. The antifungal activity and effects of MFAME towards Candida albicans and Saccharomyces cerevisiae multidrug resistant MDR(+) and sensitive MDR(-) strains was compared with those of parent compound. The results obtained indicate that MDR(+) S. cerevisiae was sensitive to MFAME as well as to AMB. MFAME exhibited the same effects on fungal cells studied as parent antibiotic. The two antibiotics, depending on the dose applied induced cell stimulation, K+ efflux, and/or had a toxic effect.

Keywords

EN

antifungal action; amphotericin B derivative; multidrug resistance; amphotericin B

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 1
• Pages: 133-140

Dates

published

2000

received

1999-10-25

Contributors

author

Joanna Szlinder-Richert

• Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland

author

Barbara Cybulska

• Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland

author

Jolanta Grzybowska

• Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland

author

Edward Borowski

• Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland

author

Rajendra Prasad

• School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India

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