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2000 | 47 | 1 | 133-140
Article title

Comparative studies on cell stimulatory, permeabilizing and toxic effects induced in sensitive and multidrug resistant fungal strains by amphotericin B (AMB) and N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME).

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Abstracts
EN
N-Methyl-N-D-fructosyl-amphotericin B methyl ester (MFAME) is a new derivative of amphotericin B, which is characterised by low toxicity to mammalian cells and good solubility in water of its salts. The antifungal activity and effects of MFAME towards Candida albicans and Saccharomyces cerevisiae multidrug resistant MDR(+) and sensitive MDR(-) strains was compared with those of parent compound. The results obtained indicate that MDR(+) S. cerevisiae was sensitive to MFAME as well as to AMB. MFAME exhibited the same effects on fungal cells studied as parent antibiotic. The two antibiotics, depending on the dose applied induced cell stimulation, K+ efflux, and/or had a toxic effect.
Publisher

Year
Volume
47
Issue
1
Pages
133-140
Physical description
Dates
published
2000
received
1999-10-25
Contributors
  • Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland
  • Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland
  • Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland
  • Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 80-952 Gdańsk, Poland
  • School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv47i1p133kz
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