Elevation of plasma fibrinogen in silent myocardial ischaemia

• Authors: Alina Grzywacz , Piotr Psuja , Maria Zozulińska , Waldemar Elikowski , Krystyna Zawilska
• Languages of publication: EN

Abstracts

EN

High plasma levels of fibrinogen and plasminogen activator inhibitor (PAI-1) are reported to be correlated with coronary heart disease. Therefore the level of fibrinogen concentration in plasma was examined and verified for the possible correlation with the previously explored PAI-1 antigen and PAI-1 activity in the pathogenesis of premature atherosclerosis (Grzywaczet al., 1998,Blood Coagul Fibrinol. 9, 245-249). Examination included only men, aged 33-46 years, who were in a stable condition for at least six months after the acute event. They were divided into two subgroups: group A (n = 14)  with and group B (n = 15) without ischaemic changes in 24 h Holter electrocardiogram. The number of involved vessels visible on the coronarography picture was similar in both groups. In the patients of group A the mean level of fibrinogen (3.92 vs 3.23 g/l, P < 0.05) was higher than in the controls (n = 15). No statistically differences were found between group B and control healthy subjects in any of the parameters measured. There were no correlation between fibrinogen concentration and PAI-1 antigen and activity levels, which were elevated in both groups of patients according to our previous study. Our results indicate that elevated levels of plasma fibrinogen and PAI-1 appeared in the group of patients with more severe disease, as revealed by silent myocardial ischaemia.

Keywords

EN

silent myocardial ischaemia; fibrinogen; plasminogen activator inhibitor-1

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 1999
• Volume: 46
• Issue: 4
• Pages: 985-989

Dates

published

1999

received

1999-07-05

accepted

1999-11-17

Contributors

author

Alina Grzywacz

• Department of Internal Medicine, J. Struś Hospital, Poznań, Poland

author

Piotr Psuja

• Department of Haematology, K. Marcinkowski University of Medical Sciences, Szkolna 8/12, 60-833 Poznań, Poland

author

Maria Zozulińska

• Department of Haematology, K. Marcinkowski University of Medical Sciences, Szkolna 8/12, 60-833 Poznań, Poland

author

Waldemar Elikowski

• Department of Internal Medicine, J. Struś Hospital, Poznań, Poland

author

Krystyna Zawilska

• Department of Haematology, K. Marcinkowski University of Medical Sciences, Szkolna 8/12, 60-833 Poznań, Poland